Publications by authors named "Pauline Aubel"
Article Synopsis
- Glioblastoma recurrence remains unavoidable even after intensive treatments, with studies showing that targeting tumor-associated macrophages can reduce tumors and improve survival.
- However, around 50% of cases in long-term studies still saw recurrences linked to fibrotic scars, which form after multiple treatments.
- Research identified these fibrotic areas as protective environments for surviving cancer cells, and blocking the associated signaling pathways improved outcomes in preclinical trials of anti-CSF-1R therapy.
Article Synopsis
- * A study looked closely at neutrophils in tumor tissues from patients with glioma (a type of brain cancer) and brain metastasis (cancer that has spread to the brain) and compared them to those in blood.
- * The researchers found that neutrophils in brain tumors are different from those in blood; they live longer and can help tumors grow by suppressing the immune response and causing inflammation.
Somatic reprogramming, which was first identified in rodents, remains poorly described in non-mammalian species. Here, we generated avian reprogrammed cells by reprogramming of chicken and duck primary embryonic fibroblasts. The efficient generation of long-term proliferating cells depends on the method of delivery of reprogramming factors and the addition of NANOG and LIN28 to the canonical OCT4, SOX2, KLF4, and c-MYC gene combination.
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- In chicks, ESCs obtained from primordial germ cells and early blastoderms can contribute to both germinal and somatic lineages, but established chick ESC lines primarily develop into somatic cells, similar to mouse EpiSC.
- Comparative microarray analysis reveals distinct transcriptomic profiles for each cell type, with key pluripotency genes found in both chick ES and blastodermal cells, suggesting that chick ES cells are more similar to mouse ES cells than
Embryonic stem (ES) cells are unique models for investigating early development and cell differentiation. First identified in mouse and later in other mammals, these cells have also been isolated in avian species. Here, using chicken as a model, we describe a set of protocols allowing the isolation, maintenance, genetic modification, differentiation, and injection of the chicken embryonic stem (cES) cells into embryos for obtaining chimeric animals.
View Article and Find Full Text PDFEmbryonic stem (ES) cells were first isolated in 1981 in the mouse from the in vitro proliferation of the inner cell mass of a 3.5 days post-coitum (dpc) blastocyst. Later on, epiblast stem cells (EpiSC) were identified from in vitro culture of the epiblast of a 6.
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