Publications by authors named "Paulina Wojtylo"
Article Synopsis
- The aryl hydrocarbon receptor (AhR) is significant in immune and metabolic processes, but its complexity and diverse ligands make drug discovery challenging.
- Researchers created quantitative structure-activity relationship (QSAR) models by analyzing 978 molecules to improve predictions of AhR activity.
- The best classification model achieved 76% accuracy and led to the development of a user-friendly web application, potentially paving the way for further studies on how ligand structure affects AhR modulation.
Developing therapeutics for inflammatory diseases is challenging due to physiological mucosal barriers, systemic side effects, and the local microbiota. In the search for novel methods to overcome some of these problems, drug delivery systems that improve tissue-targeted drug delivery and modulate the microbiota are highly desirable. Microbial metabolites are known to regulate immune responses, an observation that has resulted in important conceptual advances in areas such as metabolite pharmacology and metabolite therapeutics.
View Article and Find Full Text PDFInflammation is a key pathological driver in cystic fibrosis (CF). Current therapies are ineffective in treating and preventing the escalation of inflammatory events often exacerbated by superimposed infection. In this work, we propose a novel treatment based on the pulmonary administration of anakinra, a non-glycosylated recombinant form of IL-1Ra.
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