Correction: A system for the high-throughput measurement of the shear modulus distribution of human red blood cells.

Correction for 'A system for the high-throughput measurement of the shear modulus distribution of human red blood cells' by Amir Saadat et al., Lab Chip, 2020, 20, 2927-2936, DOI: 10.1039/D0LC00283F.

A system for the high-throughput measurement of the shear modulus distribution of human red blood cells.

Reduced deformability of red blood cells (RBCs) can affect the hemodynamics of the microcirculation and reduce oxygen transport efficiency. It is also well known that reduced RBC deformability is a signature of various physical disorders, including sepsis, and that the primary determinant of RBC deformability is the membrane shear modulus. To measure the distribution of an individual's RBC shear modulus with high throughput, we a) developed a high-fidelity computational model of RBCs in confined microchannels to inform design decisions; b) created a novel experimental system combining microfluidic flow, imaging, and image analysis; and c) performed automated comparisons between measured quantities and numerical predictions to extract quantitative measures of the RBC shear modulus for each of thousands of cells.