Publications by authors named "Paulina Strymecka"
Article Synopsis
- Researchers developed a new injectable hydrogel made from methacrylated gellan gum (Mn/GG-MA) that can be monitored in real-time using MRI for cell delivery to the central nervous system.
- The hydrogel is stable, detectable in MRI scans, and can successfully encapsulate and maintain the viability of human adipose-derived stem cells during culture.
- In animal tests, the Mn/GG-MA solution remained traceable on MRI after injection, demonstrating its potential for non-invasive cell delivery and image-guided treatments in neuroscience.
Article Synopsis
- * These hydrogels provide support for the cells during and after injection, ensuring cell survival and enabling real-time monitoring using MRI due to the added paramagnetic Mn2+.
- * The optimal hydrogel formulation, consisting of a 75:25 ratio of methacrylated gellan gum and hyaluronic acid, demonstrated controlled degradation and allowed human adipose stem cells to remain viable for up to 14 days in vitro.
The prospects for cell replacement in spinal cord diseases are impeded by inefficient stem cell delivery. The deep location of the spinal cord and complex surgical access, as well as densely packed vital structures, question the feasibility of the widespread use of multiple spinal cord punctures to inject stem cells. Disorders characterized by disseminated pathology are particularly appealing for the distribution of cells globally throughout the spinal cord in a minimally invasive fashion.
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