A New N-Substituted 1-Isoindole-1,3(2)-Dione Derivative-Synthesis, Structure and Affinity for Cyclooxygenase Based on In Vitro Studies and Molecular Docking.

Isoindoline-1,3-dione derivatives constitute an important group of medicinal substances. In this study, nine new 1-isoindole-1,3(2)-dione derivatives and five potential pharmacophores were obtained in good yield (47.24-92.