Publications by authors named "Paulina Kozakiewicz"
Mitochondria are organelles necessary for oxidative phosphorylation. The interest in the role of mitochondria in the process of carcinogenesis results from the fact that a respiratory deficit is found in dividing cells, especially in cells with accelerated proliferation. The study included tumor and blood material from 30 patients diagnosed with glioma grade II, III and IV according to WHO (World Health Organization).
View Article and Find Full Text PDFMitochondrial DNA changes can contribute to both an increased and decreased likelihood of cancer. This process is complex and not fully understood. Polymorphisms and mutations, especially those of the missense type, can affect mitochondrial functions, particularly if the conservative domain of the protein is concerned.
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- Mitochondria are crucial for cell function, and changes in mitochondrial DNA (mtDNA) may be linked to chronic diseases and cancer development, although the full process is complex and not fully understood.
- Specific mtDNA haplogroups might either increase the risk of cancer or help reduce it, with mutations potentially influencing both mitochondrial and nuclear DNA due to reactive oxygen species.
- Certain mtDNA polymorphisms, such as G5913A, are associated with conditions like prostate cancer and hypertension, highlighting the role of mtDNA variations in cancer prognosis and progression.
Despite the development of standard therapies, including surgery, radiotherapy and chemotherapy, survival rates for head and neck squamous cell carcinoma (HNSCC) have not changed significantly over the past three decades. Complete recovery is achieved in <50% of patients. The treatment of advanced HNSCC frequently requires multimodality therapy and involves significant toxicity.
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