The Variability of Tryptophan Metabolism in Patients with Mixed Type of Irritable Bowel Syndrome.

Patients with a mixed type of irritable bowel syndrome (IBS-M) experience constipation and diarrhea, which alternate between weeks or months. The pathogenesis of this syndrome is still little understood. The aim of the study was mainly to evaluate the urinary excretion of selected tryptophan (TRP) metabolites during the constipation and diarrhea periods of this syndrome.

The Usefulness of the Low-FODMAP Diet with Limited Tryptophan Intake in the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome.

(1) Background: A low-FODMAP diet is often recommended in the treatment of irritable bowel syndrome, but it does not improve abdominal symptoms in all patients, and an alternative diet is desirable. The purpose of this study was to evaluate the efficacy of a low-FODMAP diet with a concomitant reduction in tryptophan (TRP) intake in irritable bowel syndrome with diarrhea predominance (IBS-D) in relation to its metabolism via the serotonin and kynurenine pathways. (2) Methods: 40 healthy people (Group I, Controls) and 80 patients with IBS-D were included in the study.

Reduced Intake of Dietary Tryptophan Improves Beneficial Action of Budesonide in Patients with Lymphocytic Colitis and Mood Disorders.

Lymphocytic colitis (LC) is a gastrointestinal (GI) tract disease with poorly known pathogenesis, but some environmental and lifestyle factors, including certain dietary components, may play a role. Tryptophan is an essential amino acid, which plays important structural and functional roles as a component of many proteins. It is important in the development and maintenance of the body, in which it is metabolized in two main pathways: kynurenine (KYN) and serotonin.

Changes in Tryptophan Metabolism on Serotonin and Kynurenine Pathways in Patients with Irritable Bowel Syndrome.

(1) Background: L-tryptophan is a substrate for the synthesis of many biological compounds through the serotonin and kynurenine pathways. These compounds have a significant influence on gastrointestinal functions and mental processes. The aim of the study was to evaluate the urinary excretion of selected tryptophan metabolites in patients with constipation-predominant and diarrhoea-predominant irritable bowel syndrome (IBS-C and IBS-D, respectively), related to somatic and mental symptoms.

Beneficial Effect of Increased Tryptophan Intake on Its Metabolism and Mental State of the Elderly.

The elderly often suffer from sleep disorders and depression, which contribute to mood disorders. In our previous work, we showed that elderly individuals with mood disorders had a lower intake of TRP and recommended a TRP-based dietary intervention to improve the mental state of such individuals. In this work, we assessed the impact of a TRP-rich diet on the mental state of, and TRP metabolism in, elderly individuals with mood disorders.

The clinical value of breath ammonia determination in patients with irritable bowel syndrome.

Unlabelled: Gastrointestinal tract is the major source of ammonia (NH3). NH3 is produced by bacterial hydrolysis of urea as well as by bacterial protein deamination. The intensity of this process depends on protein intake and the amount of gut bacteria.

The role of serotonin in pathogenesis of unclassified irritable bowel syndrome.

Unlabelled: The pathogenesis of irritable bowel syndrome (IBS) has not been clearly understood. Numerous factors, including neurotransmitters, can interfere with the functions of the digestive tract.

Aim: The aim of present study was to determine the secretion and metabolism of serotonin in patients with unclassified irritable bowel syndrome (IBS-U).

Antimicrobial treatment improves tryptophan metabolism and mood of patients with small intestinal bacterial overgrowth.

Background: Optimal composition of intestinal bacteria is an essential condition for good health. Excessive growth of these bacteria can cause various ailments. The aim of this study was to assess the mental state and gastrointestinal complaints of patients with small intestinal bacterial overgrowth (SIBO) in relation to tryptophan metabolism and rifaximin treatment.

Altered Tryptophan Metabolism on the Kynurenine Pathway in Depressive Patients with Small Intestinal Bacterial Overgrowth.

The causes of depression are diverse and are still not fully understood. Recently, an increasing role is attributed to nutritional and inflammatory factors. The aim of this study was to evaluate selected metabolites of the tryptophan kynurenine pathway in depressive patients with small intestinal bacterial overgrowth (SIBO).

Altered tryptophan metabolism in patients with recurrent functional abdominal pain.

Unlabelled: The causes of functional abdominal pain are still unclear. The role of food factors in their pathogenesis has been assessed by many researches, but the obtained results are varied.

Aim: The aim of present study was to evaluate metabolism of tryptophan, which is substrate for serotonin synthesis and other bioactive compounds, in patients with recurrent functional abdominal pain.

Serotonin Pathway of Tryptophan Metabolism in Small Intestinal Bacterial Overgrowth-A Pilot Study with Patients Diagnosed with Lactulose Hydrogen Breath Test and Treated with Rifaximin.

Small intestinal bacterial overgrowth (SIBO) is a condition associated with diverse clinical conditions and there is no gold standard in its diagnosis and treatment. Tryptophan (Trp) metabolism may be involved in etiology of gastrointestinal diseases and is regulated by intestinal microbiota. In our study we investigated aspects of the serotonin (5-HT) pathway of Trp metabolism in three groups of individuals based on the hydrogen concentration in the lactulose hydrogen breath test (LHBT): controls (<20 ppm) and SIBO patients (≥20 ppm), with diarrhea (SIBO-D) or constipation (SIBO-C).

[The role of intraepithelial lymphocytes in pathogenesis of small intestinal bacterial overgrowth syndrome].

Unlabelled: Small intestinal bacterial overgrowth (SIBO) is a frequent cause of chronic abdominal complaints. So far, a lot information has been gathered on its pathogenesis but are still doubts that raise question why its causes chronic diarrhea in some and constipation in other patients.

Aim: The aim of the study was to assess the number of endothelial lymphocytes (IELs) in the duodenal and ileum mucosa in patients with SIBO with dominant diarrhea (SIBO-D) and dominant constipation (SIBO-C).

The value of melatonin supplementation in postmenopausal women with Helicobacter pylori-associated dyspepsia.

Background: Dyspeptic syndrome is particularly common in postmenopausal women in the form of epigastric pain. The aim of the study was to assess the role of melatonin in chronic dyspepsia in this group of women, and examine the role of Helicobacter infection.

Methods: The study comprised 152 subjects including 30 healthy women (Group I), 60 women with asymptomatic H.

Tryptophan Intake and Metabolism in Older Adults with Mood Disorders.

The role of serotonin in the pathogenesis of depression is well-documented, while the involvement of other tryptophan (TRP) metabolites generated in the kynurenine pathway is less known. The aim of this study was to assess the intake and metabolism of TRP in elderly patients with mood disorders. Ninety subjects in three groups, 30 subjects each, were enrolled in this study: controls (healthy young adults, group I) and elderly individuals without (group II) or with (group III) symptoms of mild and moderate depression, as assessed by the Hamilton Depression Rating Scale (HAM-D) and further referred to as mood disorders.

[The influence of serotonin on psychosomatic symptoms in patients with functional dyspepsia].

Unlabelled: The pathogenesis of functional dyspepsia is remains unknown. The diagnosis is based on subjective symptoms. However, many effort are being made in searching for the causes and objective indices which could facilitate the diagnosis and the treatment of this disease.

Usefulness of the hydrogen breath test in patients with functional dyspepsia.

Introduction: The pathogenesis of functional dyspepsia is complex and not well understood. Therefore, in this disease there should be considered involvement of different pathogenic factors, including intestinal bacteria.

Aim: To evaluate the results of the hydrogen breath test in relation to the clinical picture of functional dyspepsia.

[Zaburzenia czynnościowe przewodu pokarmowego u osób z przerostem bakteryjnym jelita cienkiego].

Unlabelled: Small intestinal bacterial overgrowth (SIBO) is a frequent cause of chronic abdominal complaining.

Aim: The aim of this study was to assess the prevalence of the functional disorders in this group patients.

Materials And Methods: The study was conducted in a group of 426 subjects, aged 22-65, including 294 women and 132 men with intestinal functional diseases, as defined in Rome IV Criteria.

[The number of intraepithelial lymphocytes in digestive tract in patients with IgG-dependent intolerance of cereal products].

Unlabelled: Abnormal reaction of food antigens cause a variety disorders of gastrointestinal tract. It is not clear why exactly the same products provoke diarrhea or constipation.

Aim: The aim of this study was to assess the number of intraepithelial lymphocytes (IEL) in different parts of gastrointestinal tract in patients with specific IgG antibodies against wheat and secale products.

Changes in the lipid profile of patients with asymptomatic and symptomatic helicobacter pylori infection.

Objective: Introduction: Helicobacterpylori ( H. pylori) infection often coexists with coronary artery disease, but the causal relationship is not clear as yet. The aim: to assess the lipidogram of patients with asymptomatic and symptomatic H.

Therapeutic efficacy of amoxicillin and rifaximin in patients with small intestinal bacterial overgrowth and infection.

Introduction: Small intestinal bacterial overgrowth (SIBO) may coexist with infection, which can be the cause of chronic gastrointestinal complaints.

Aim: Evaluation of the therapeutic efficacy of amoxicillin and rifaximin in the treatment of these diseases.

Material And Methods: The lactulose hydrogen breath test (LHBT) and the urea breath test (C-UBT) were performed in 116 patients.

[Thyroid dysfunction in patients with small intestinal bacterial overgrowth].

Unlabelled: Small intestinal bacterial overgrowth (SIBO), similarly as thyroid diseases, is characterized by chronic diarrhea or constipation, but it is not known whether there is a causal relationship between these disorders.

Aim: The aim of the study was to assess thyroid function indices in different clinical forms of SIBO.

Materials And Methods: The study was performed in 34 patients with diarrhea predominant SIBO (group I), 30 with constipation predominant SIBO (group II) and 30 clinically healthy subjects (control group - K).

[Evaluation of oro-cecal transit time in patients with irritable bowel syndrome with cereal products intolerance].

Unlabelled: The main symptoms of irritable bowel syndrome (IBS) include abnormal frequency of bowel movements. On this basis, three main clinical types of the disease have been distinguished, i.e.