Publications by authors named "Paulina Donicz"
Article Synopsis
- The study emphasizes the need for a personalized approach to schizophrenia due to its polygenic nature, seeking laboratory biomarkers from various sources including blood, brain imaging, and patient self-reports.
- Metabolomics research involving serum samples from patients and healthy volunteers identified three key biochemical indicators—cortisol, glutamate, and lactate—that correlate with clinical assessments and imaging results.
- The findings show significant relationships between blood lactate levels and clinical/neuroimaging parameters, suggesting that changes in lactate and cortisol levels may reflect underlying immunological shifts and brain chemistry relevant to schizophrenia subtypes.
Schizophrenia is characterized by complex metabolic dysregulations and their consequences. Until now, numerous theories have explained its pathogenesis, using a spectrum of available technologies. We focused our interest on lipid profile-periphery high-density cholesterol level and lipoproteins in the human brain and compared magnetic resonance imaging (MRI) scans of patients with schizophrenia and the healthy group.
View Article and Find Full Text PDFIntroduction: The standard care of schizophrenia patients is based on the assessment of their psychotic behavior, using interview-based, subjective scales that measure symptoms severity. We aimed at defining easily accessible and inexpensive blood-derived clinical diagnostic parameters that might serve as objective markers in the prediction of the effects of pharmacological treatment of schizophrenia patients.
Methods: A total of 40 patients with schizophrenia diagnosis according to ICD 10 during psychotic decompensation were included in the study.
Thyroid abnormalities, including mild forms of hypothyroidism and hyperthyroidism, are reported as risk factors for the development of a number of neuropsychiatric disorders, including schizophrenia. The diagnostic process still takes into account the extreme ranges of the accepted reference values for serum TSH since the concentration of free thyroxine in the serum does not change by definition. TSH mU/L cut-off values in psychiatric patients are currently clinically considered in the case of extremely high serum TSH levels (>4.
View Article and Find Full Text PDFIntroduction: Complications occurring after neurosurgical procedures which lead to reoperations are associated with poor treatment outcomes. The aim of our study was to establish predictive factors of unplanned early reoperations after intracranial meningioma removal.
Materials And Methods: We retrospectively analyzed 177 patients who underwent craniotomy due to an intracranial meningioma.
Background: Complications after neurosurgical procedures that lead to reoperation are associated with poor outcome and economic costs. Therefore the aim of our study was to establish predictors of reoperation due to complications after cranial neurosurgery.
Methods: We retrospectively analyzed 875 patients who underwent a cranial neurosurgical procedure.