Publications by authors named "Paulina Buda"
Article Synopsis
- The IL-12/23 signaling pathway is crucial in the development of psoriasis, and treatments targeting it can sometimes fail to provide sufficient responses.
- The study aimed to analyze how mRNAs and miRNAs related to this pathway behave in cultured human keratinocytes when exposed to lipopolysaccharide A (LPS) and then treated with adalimumab.
- Results showed that adalimumab significantly impacted the expression of specific genes and their interactions, particularly enhancing the expression of JAK3 and related miRNAs while silencing SOCS3 and IL-6 after LPS exposure.
Psoriasis is a chronic autoimmune disease that affects 1-3% of the population. The pathomechanism of psoriasis development is complex, but genetic (non-modifiable) factors play a key role. However, the importance of environmental factors and lifestyle choices, such as the diet, alcohol consumption, and smoking, is increasing.
View Article and Find Full Text PDFArticle Synopsis
- Cyclosporin A (CsA) is used to treat moderate to severe psoriasis vulgaris, where the MAPK signaling pathway plays a crucial role in disease development, and DUSPs help regulate this pathway by dephosphorylation.
- The study investigates the expression changes of DUSP1-7 and their regulating micro RNAs (miRNAs) in HaCaT cells exposed to LPS-induced inflammation and CsA treatment, using molecular analysis techniques.
- Results indicate significant expression changes in DUSP1 and DUSP5, with specific miRNAs found to regulate various DUSP expressions, although DUSP1-7 protein levels were not detected after CsA exposure.
Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer.
J Cancer Res Clin Oncol
August 2023
Purpose: Changes in the activity of endothelins and their receptors may promote neoplastic processes. They can be caused by epigenetic modifications and modulators, but little is known about endothelin-3 (EDN3), particularly in endometrial cancer. The aim of the study was to determine the expression profile of endothelin family and their interactions with miRNAs, and to assess the degree of EDN3 methylation.
View Article and Find Full Text PDF