Publications by authors named "Paulina Achita"
Progression to malignancy in oral potentially malignant disorders: a retrospective study of 5,036 patients in Ontario, Canada.
Oral Surg Oral Med Oral Pathol Oral Radiol
October 2023
Article Synopsis
- The study aimed to find the rate of malignant transformation (MT) of oral potentially malignant disorders (OPMDs) and identify associated risk factors.
- The data from 2001-2015 showed a 6.4% rate of transformation to oral squamous cell carcinoma (OSCC), typically taking about 51.2 months, with older age and non-smoking status linked to higher risks.
- The findings indicated that the highest MT rates occurred in the tongue, floor of the mouth, and gingiva, with certain subtypes like atypical verrucous-papillary lesions showing significantly higher progression rates than conventional mild dysplasia.
To explore the potential of expanded healthy donor-derived allogeneic CD4 and CD8 double-negative cells (DNT) as a novel cellular immunotherapy for leukemia patients. Clinical-grade DNTs from peripheral blood of healthy donors were expanded and their antileukemic activity and safety were examined using flow cytometry-based killing assays and xenograft models against AML patient blasts and healthy donor-derived hematopoietic cells. Mechanism of action was investigated using antibody-mediated blocking assays and recombinant protein treatment assays.
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