Publications by authors named "Paulette Nacpil-Dominguez"
Article Synopsis
- Sulfonylureas (SUs), like gliclazide and glimepiride, are commonly used medications for managing type 2 diabetes in the Philippines, and the study aimed to explore the genetic factors affecting their effectiveness.
- The research involved 252 participants across two studies, where genetic testing was conducted to identify associations between genetic variants and the individual responses to these medications.
- Results showed that certain genetic variants were significantly linked to poor responses to gliclazide and glimepiride, suggesting that understanding these genetic factors could improve treatment strategies for diabetes in the Filipino population.
Purpose: A study among Filipinos revealed that only 15% of patients with diabetes achieved glycemic control, and poor response to metformin could be one of the possible reasons. Recent studies demonstrate how genetic variations influence response to metformin. Hence, the present study aimed to determine genetic variants associated with poor response to metformin.
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