Publications by authors named "Paula de S Santos"
Type 2 diabetes mellitus is a global health problem, placing patients at a higher risk of developing cardiovascular diseases and cancer. This study investigates the antidiabetic potential of Cassia bakeriana bark extracts and fractions. We evaluate their ability to inhibit α-amylase and α-glucosidase enzymes and advanced glycation end-products (AGEs).
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- Despite its fragile nature, a harmful bacterium is a leading cause of foodborne illness, primarily transmitted through chicken meat.
- Extreme stress causes this bacterium to enter a "viable but non-culturable" (VBNC) state, which was found to develop completely in an average of 26 days under stress conditions.
- Analysis showed morphological changes when transitioning from its usual form to VBNC, along with significant impacts on host cells and changes in the expression of protective metabolites.
Development of peptide vaccines through the phage display technology is a powerful strategy that relies on short peptides expressed in the phage capsid surface to induce highly targeted immune responses. Phage display-derived immunogenic peptides can be used directly as a phage-fused peptide reagent or as a synthetic peptide with specific modifications, according to target molecule and disease pathogen/parasite. Peptides' selection (mimotopes) can be performed against monoclonal or polyclonal antibodies to disclose determinant regions (epitopes) that can induce a neutralizing response.
View Article and Find Full Text PDFIn the present work, we report the isolation and partial biochemical characterization of BpLec, a C-type lectin purified from Bothrops pauloensis venom by one chromatographic step on an affinity agarose column immobilized with d-galactose. This protein was homogeneous by SDS-PAGE under reducing and nonreducing conditions, and was shown to be a 33.6 kDa homodimer by MALDI TOF analysis.
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