Publications by authors named "Paula de Carvalho"
Context.—: The main objectives of the Paris System are to detect high-grade urothelial carcinoma, to standardize morphologic criteria and the cytopathologic report, to reduce the prevalence of the atypia category, and to improve the malignancy risk stratification.
Objective.
Article Synopsis
- Transgender women face high rates of both HIV and gender-based violence (GBV), which negatively impacts their health care and treatment outcomes.
- A study conducted in Brazil assessed how lifetime experiences of GBV affected the retention of transgender women living with HIV in care and their ability to achieve viral suppression.
- Results showed that a significant portion of participants experienced physical (62%) and sexual violence (45%), with lower rates of retention in care (58%) and viral suppression (35%) observed at follow-up, indicating a potential link between GBV and poorer health outcomes.
Analgesia and Side Effects of Codeine Phosphate Associated with Paracetamol Versus Oxycodone After the Extraction of Mandibular Third Molars: A Randomized Double-Blind Clinical Trial Using the Split-Mouth Model.
J Maxillofac Oral Surg
September 2022
Purpose: To assess the analgesia and side effects of 10 mg oxycodone as compared to 30 mg of codeine phosphate associated with 500 mg of paracetamol after bilateral lower third molar extraction.
Methods: This is a prospective, randomized, double-blind study applied to a sample of 16 patients. They were evaluated for seven days postoperatively, and the mean score of the visual analogue scale (VAS) of pain between test and control medications was assessed by the Wilcoxon distribution.
Effect of Light Emission Through an Optical Fiber Device on the Bond Strength of a Hollow Experimental Intraradicular Post.
J Adhes Dent
August 2022
Purpose: To evaluate the effect of irradiation with an optical-fiber device on the bond strength of hollow and partially opaque intraradicular posts.
Materials And Methods: An optical-fiber accessory tip was attached to a light-curing unit to emit light through the central hollow of an experimental fiberglass post. The samples were divided into 4 groups (n = 80) according to the protocol (Variolink N [light cured] or Multilink N [dual-curing luting material]) and the light-curing mode (performed conventionally or with the optical fiber): GF: light-curing luting material; GFF: light-curing luting material and optical fiber; GD: dual-curing luting material; GDF: dual-curing luting material and optical fiber.
High prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazil.
Infect Genet Evol
November 2020
Article Synopsis
- A study in Central-West Brazil investigated the prevalence, risk factors, and genetic diversity of hepatitis C virus (HCV) among crack cocaine users, finding a 4.5% infection rate.
- Among the infected, various HCV genotypes were identified, with the most common being 1a.
- The research highlights a significant association between previous intravenous drug use and HCV infection, suggesting the need for public health interventions like harm reduction and testing services for users in this area.
Article Synopsis
- Brown adipose tissue (BAT) helps regulate energy balance and is influenced by melatonin, which affects its metabolism and molecular activity in response to factors like temperature and diet.
- Experiments with male rats showed that those without melatonin (pinealectomized rats) had decreased expression of important thermogenic genes when exposed to high-fat diets or cold, while melatonin-treated rats showed increased gene expression linked to energy production.
- The absence of melatonin disrupts BAT's ability to adapt to metabolic stress, but melatonin treatment can restore and enhance the expression of key genes and proteins involved in thermogenesis, highlighting its crucial role in maintaining body homeostasis.
Objectives: To evaluate motivations to perform an elective single embryo transfer (e-SET).
Methods: Cross-sectional surveys to reproductive medicine specialists and to infertile patients undergoing assisted reproductive treatments.
Results: In the physician's survey (n = 278), we found that the main reasons for not offering e-SET were the physicians' belief that patients prefer optimizing the pregnancy rates regardless of the potential complications (57.
The objective of this controlled experimental study was to analyze the changes in the Achilles tendons of rats with experimentally induced tendinitis after treatment with platelet-rich plasma (PRP) and/or laser therapies by histometry to quantify fibroblasts and by Raman spectroscopy to determine the biochemical concentration of collagen types I and III. Fifty-four male Wistar rats were divided into six treatment groups: control (G1); PRP only (G2); irradiation with 660 nm laser (G3); irradiation with 830 nm laser (G4); PRP plus 660 nm laser irradiation (G5); and PRP plus 830 nm laser irradiation (G6). Injuries (partial tenotomy) were inflicted in the middle third of the Achilles tendon, with PRP added prior to suture in the appropriate experimental groups.
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- The study aimed to evaluate the impact of low-level laser therapy (LLLT) and platelet-rich plasma (PRP) on tendon healing in male rats after a partial tenotomy.
- A total of 54 rats were divided into six treatment groups, with variations including LLLT at two different wavelengths (660 nm and 830 nm) and combinations with PRP.
- Results indicated that the combination of PRP with LLLT significantly increased the deposition of collagen type I, suggesting enhanced tendon regeneration compared to other treatments.
In a previous study, our group verified that 100% of mice survived to a lethal dose of Candida albicans following pretreatment with concanavalin-A (Con-A) for 3 days. This work proposed to investigate whether treatment could mediate an adaptative immune response involving T(H) 17 cells. A significant increase in IL-17 levels at 6 h postinfection was observed and was maintained up to 18 h in the Con-A group, whereas in control mice, a reduction in this cytokine was verified.
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