Altered fronto-amygdalar functional connectivity predicts response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder.

Background: Based on findings from adults with obsessive-compulsive disorder (OCD), this study examined alterations in resting-state functional connectivity (rs-fc) between the basolateral amygdala (BLA) and the ventromedial prefrontal cortex (vmPFC) in children and adolescents with OCD. We also assessed whether such BLA-vmPFC connectivity changed with or predicted response to exposure and response prevention (E/RP), the first-line treatment for pediatric OCD, given the involvement of these regions in fear processing, regulation, and extinction learning-a probable mechanism of action of E/RP.

Methods: Resting state functional magnetic resonance imaging scans were acquired from 25 unmedicated, treatment-naïve pediatric patients with OCD (12.

Correction: Altered network connectivity predicts response to cognitive-behavioral therapy in pediatric obsessive-compulsive disorder.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Altered network connectivity predicts response to cognitive-behavioral therapy in pediatric obsessive-compulsive disorder.

Obsessive-compulsive disorder (OCD) is commonly associated with alterations in cortico-striato-thalamo-cortical brain networks. Yet, recent investigations of large-scale brain networks suggest that more diffuse alterations in brain connectivity may underlie its pathophysiology. Few studies have assessed functional connectivity within or between networks across the whole brain in pediatric OCD or how patterns of connectivity associate with treatment response.

Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder.

Background: Cognitive behavioral therapy (CBT) is an effective, first-line treatment for pediatric obsessive-compulsive disorder (OCD). While neural predictors of treatment outcomes have been identified in adults with OCD, robust predictors are lacking for pediatric patients. Herein, we sought to identify brain structural markers of CBT response in youth with OCD.

Distinctions between autobiographical memory specificity and detail: Trajectories across cue presentations.

Autobiographical memory is central to identity and self-awareness, but individuals with depression and Post-Traumatic Stress Disorder tend to have overgeneral memories. Recent research has suggested that the ability to retrieve specific memories and individual differences in the amount of detail in specific memories are independent (Kyung, Yanes-Lukin, & Roberts, 2016). We re-analyzed data from Kyung et al.

Stepped Care Interpersonal Psychotherapy Treatment for Depressed Adolescents: A Pilot Study in Pediatric Clinics.

Adolescents with depression are at risk for negative long-term consequences and recurrence of depression. Many do not receive nor access treatment, especially Latino youth. New treatment approaches are needed.

A pilot study of Brief IPT-A delivered in primary care.

Objective: The objective was to examine the feasibility, acceptability and preliminary effectiveness of a brief version of Interpersonal Psychotherapy for Depressed Adolescents (BIPT-A) in low-income Latino adolescents treated in an urban pediatric primary care setting.

Method: Ten adolescents, ages 12 to 19 years, who were referred by their pediatric providers and met criteria for a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, depression diagnosis participated. Participants received 6 weekly sessions of BIPT-A.

Specificity and detail in autobiographical memory: Same or different constructs?

Research on autobiographical memory has focused on whether memories are coded as specific (i.e., describe a single event that happened at a particular time and place).

Cultural Competency and Its Effect on Treatment Outcome of IPT-A in School-Based Health Clinics.

Background: This paper assesses acculturation and ethnic matching of therapist and patient as predictors and moderators of treatment outcome in a 12-week effectiveness study of Interpersonal Psychotherapy for depressed adolescents (IPT-A) versus treatment as usual (TAU). The treatment was delivered in school-based health clinics in which care was provided for a predominantly Latino patient population.

Methods: Birthplace, length of residence in the United States (U.