Evaluation of epithelial-to-mesenchymal transition and Ki-67 index in aggressive papillary thyroid cancer.

Objectives: The present study aims to characterize immunohistochemical features of markers associated with Epithelial-Mesenchymal Transition (EMT) and proliferative activity that could lead to death in Papillary Thyroid Cancer (PTC).

Methods: Clinical data and tumor material were retrospectively collected. The patients were separated into death from PTC (Group 1), metastatic cases with indolent behavior (Group 2) and non-metastatic indolent PTC (Group 3).

Papillomas of the breast: factors associated with underestimation.

The distinction between benign and malignant papilloma of the breast through percutaneous needle biopsy can be difficult because of limited samples; the underestimation rate can be up to 25%. The aim of this study is to identify clinical and histological factors associated with underestimation, invasive ductal carcinoma, or ductal in-situ carcinoma (DCIS) of the breast found in surgical specimens from papillary lesions. This may contribute toward selection of patients for a follow-up strategy without the need for surgical excision.

[Geography, health and urban development in São Paulo state at the turn of the twentieth century: Domingos Jaguaribe and the construction of the Climate Resort of Campos do Jordão].

The resort towns created in the early 1900s are prime objects for studying the relationship between public health policies and urban and social development. This article analyzes the social and institutional vectors involved in the creation of the resort town of Campos do Jordão from the perspective of the career and works of physician, geographer and businessman Domingos Nogueira Jaguaribe Filho. Geographical studies, medical knowledge and the precepts of urbanization combined with private and development interests in the symbolism and concrete manifestation of the "Brazilian Switzerland".

Cervical lymphadenopathy in childhood: nasopharyngeal carcinoma as a challenging diagnosis.

Nasopharyngeal carcinoma (NPC) is a carcinoma that arises from the nasopharyngeal mucosa and differs from other head and neck carcinomas by its unique histologic, epidemiologic, and biologic characteristics. NPC is rare in most countries, especially Europe and North America. However, it has a high incidence in several regions of South China.

[The Boletim Médico: the tuberculosis specialists' prescription for curing the city of São José dos Campos (1930-1935)].

The article explores the transformation of the city of São José dos Campos, which in 1935 received the official designation of "health resort" for the treatment of pulmonary tuberculosis. Research of Boletim Médico (a periodical published by the city's tuberculosis specialists) and of other, related sources grounds this analysis of both the motives and the strategies of this professional group when the quiet little town of São José dos Campos was transformed into a major center for tuberculosis cures. This examination of the technical arguments in support of the project reinforces the idea that the city's status as a health resort was both a threat to city residents and also a driving force behind the local economy, based almost exclusively on exploiting the disease through the 1950s.

[Health resort, industrial city: urban space and health policy in São José dos Campos, São Paulo, Brazil].

This study is part of the renewed theoretical and conceptual approach to space in health policies. The key potential of this approach lies in dealing with the organization of space as a product of relations between society and state power, influenced by the economy and enabled by politics. When understood as a social construction, such space provides the material basis for a historical narrative, allowing a better understanding of how policies are formulated and implemented in urban space.