AM251, a cannabinoid receptor 1 antagonist, prevents human fibroblasts differentiation and collagen deposition induced by TGF-β - An in vitro study.

Previous studies showed that cannabinoid 1 receptor (CB) is linked with skin fibrosis and scar tissue formation in mice. Therefore, the topical use of cannabinoids may have a role in the prevention or treatment of local fibrotic and wound healing diseases as hypertrophic scars or keloids. In this study, we asked whether CB activation or inactivation would change fibroblast differentiation into myofibroblast and collagen deposition in skin human fibroblast.

A new role for anandamide: defective link between the systemic and skin endocannabinoid systems in hypertrophic human wound healing.

The use of cannabinoids to treat fibrotic skin diseases is an emergent issue. Therefore, we aimed to evaluate systemic and skin endocannabinoid responses in the wound-healing process in humans. A prospective study was performed in 50 patients who underwent body-contouring surgery.