The Role of CXCR3 and Its Chemokine Ligands in Skin Disease and Cancer.

Chemokines and their receptors play an important role in the recruitment, activation and differentiation of immune cells. The chemokine receptor, CXCR3, and its ligands, CXCL9, CXCL10, and CXCL11 are key immune chemoattractants during interferon-induced inflammatory responses. Inflammation of the skin resulting from infections or autoimmune disease drives expression of CXCL9/10/11 and the subsequent recruitment of effector, CXCR3 T cells from the circulation.

HPV16-E7-Specific Activated CD8 T Cells in E7 Transgenic Skin and Skin Grafts.

Human papillomavirus (HPV) 16 E7 (E7) protein expression in skin promotes epithelial hyperproliferation and transformation to malignancy. Grafts of murine skin expressing E7 protein as a transgene in keratinocytes are not rejected from immunocompetent recipients, whereas grafts expressing ovalbumin (OVA), with or without coexpression of E7 protein, are promptly rejected, demonstrating that E7-associated non-antigen-specific local immunosuppression is not a major determinant of lack of rejection of E7 transgenic skin. To determine whether failure of rejection of E7 skin grafts is due to failure to attract E7-specific effector T cells, E7- and OVA-specific effector CD8 T cells, activated , were transferred to animals bearing E7 transgenic skin grafts.

Batf3 selectively determines acquisition of CD8 dendritic cell phenotype and function.

Batf3 is a transcription factor that impacts the development of CD103 tissue-resident dendritic cells (DCs). However, whether Batf3 is absolutely required for the development of CD8 DCs remains controversial. Id2 is required for CD8 DC development.