Publications by authors named "Paula Sobieszczanska"
Article Synopsis
- Two mouse models, one with translated (HD/100Q) and one with nontranslated (HD/100CAG) human mutant HTT, were created to study their effects on behavior and molecular changes over 21 months.
- Results showed both models displayed behavioral alterations and gene deregulations, with the nontranslated model exhibiting less severe impairments but notable anxiety increases due to mutant HTT RNA, suggesting its minor role in HD pathogenesis.
Article Synopsis
- * After analyzing over 1,000 plant accessions, we found that some gene clusters (like those for tirucalladienol and marneral) showed little genetic variation, while others (like arabidiol/baruol) were more diverse, with notable changes in gene structure.
- * The study emphasizes how these evolving MGCs impact plant adaptation and the variations in traits, such as root growth dynamics related to climate conditions.
Background: Nicotiana benthamiana has been widely used in laboratories around the world for studying plant-pathogen interactions and posttranscriptional gene expression silencing. Yet the exploration of its transcriptome has lagged behind due to the lack of both adequate sequence information and genome-wide analysis tools, such as DNA microarrays. Despite the increasing use of high-throughput sequencing technologies, the DNA microarrays still remain a popular gene expression tool, because they are cheaper and less demanding regarding bioinformatics skills and computational effort.
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