Inspiratory vs. expiratory pressure-volume curves to set end-expiratory pressure in acute lung injury.

Objective: To study the effects of two levels of positive end-expiratory pressure (PEEP), 2 cm H(2)O above the lower inflection point of the inspiratory limb and equal to the point of maximum curvature on the expiratory limb of the pressure-volume curve, in gas exchange, respiratory mechanics, and lung aeration.

Design And Setting: Prospective clinical study in the intensive care unit and computed tomography ward of a university hospital.

Patients: Eight patients with early acute lung injury.