Population pharmacokinetic modelling of indium-based quantum dot nanoparticles: preclinical in vivo studies.

There is considerable interest in biomedical applications of quantum dot (QD) nanoparticles, in particular their use as imaging agents for diagnostic applications. In order to investigate the in vivo biodistribution and the potential toxicity of quantum dots (QDs), it is crucial to develop pharmacokinetic (PK) models as basis for prediction of QDs exposure profiles over time. Here, we investigated the in vivo biodistribution of novel indium-based QDs in mice for up to three months after intravenous administration and subsequently developed a translational population PK model to scale findings to humans.

The synthesis of rare earth fluoride based nanoparticles.

The requirement for narrow emission profiles and systems that do not include metals perceived to be cytotoxic, has led to an increase in the reports on rare-earth (Ln) materials, with fluoride-based materials in particular attracting attention. This class of compounds includes rare-earth fluorides (LnF(3)), rare-earth oxyfluorides (LnOF) and alkali metal rare-earth fluorides (MLnF(4), where M represents an alkali metal). Here we will describe the main reactions outlining key developments in roughly chronological order.

Extended one-dimensional self-assemblies of nanoparticles; nano-rouleaux formations.

In this communication, we report the unusually extensive uni-directional self-assembly of nanoparticulate EuF(3) and discuss the origins behind such behaviour.

Ionic liquid passivated CdSe nanocrystals.

CdSe nanoparticles have been prepared, using the phosphonium ionic liquid trihexyl(tetradecyl)phosphonium bis(2,4,4-trimethylpentylphosphinate) as a solvent and capping agent.