Publications by authors named "Paula Punzon-Jimenez"
Age-associated myometrial dysfunction can prompt complications during pregnancy and labor, which is one of the factors contributing to the 7.8-fold increase in maternal mortality in women over 40. Using single-cell/single-nucleus RNA sequencing and spatial transcriptomics, we have constructed a cellular atlas of the aging myometrium from 186,120 cells across twenty perimenopausal and postmenopausal women.
View Article and Find Full Text PDFHigh-grade serous ovarian carcinoma (HGSOC) represents the most common form of epithelial ovarian carcinoma. The absence of specific symptoms leads to late-stage diagnosis, making HGSOC one of the gynecological cancers with the worst prognosis. The cellular origin of HGSOC and the role of reproductive hormones, genetic traits (such as alterations in P53 and DNA-repair mechanisms), chromosomal instability, or dysregulation of crucial signaling pathways have been considered when evaluating prognosis and response to therapy in HGSOC patients.
View Article and Find Full Text PDFThe impact of the female genital tract microbiome in women health and reproduction: a review.
J Assist Reprod Genet
October 2021
Article Synopsis
- * Research was conducted by analyzing articles from PubMed related to genital tract microbiota and its effects on reproduction, revealing a dominance of Lactobacillus species in the vagina and endometrium, but more variation in the fallopian tubes and ovaries.
- * The findings suggest that a stable and Lactobacillus-rich microbiome is linked to better reproductive outcomes; however, further research is needed to clarify the connections between microbiota, fertility issues, and the development of new diagnostic and treatment tools for reproductive