Morphological alterations induced by the exposure to TiO nanoparticles in primary cortical neuron cultures and in the brain of rats.

Nowadays, nanoparticles (NPs) of titanium dioxide (TiO) are abundantly produced. TiO NPs are present in various food products, in paints, cosmetics, sunscreens and toothpastes. However, the toxicity of TiO NPs on the central nervous system has been poorly investigated until now.

A new method allowing long-term potentiation recordings in hippocampal organotypic slices.

Background: Hippocampal organotypic slices are used to improve the understanding of synaptic plasticity mechanisms because they allow longer term studies compared to acute slices. However, it is more delicate to keep cultures alive in the recording system outside  conditions. Experiments from the organotypic cultures are common but the handling of slices is rarely described in the literature, even though tissue preservation is crucial.

Regional and time-dependent neuroprotective effect of hypothermia following oxygen-glucose deprivation.

The neuroprotective effect of hypothermia has been demonstrated in in vivo and in vitro models of cerebral ischemia. In regard to the hippocampus, previous studies have mainly focused on CA1 pyramidal neurons, which are very vulnerable to ischemia. But the dentate gyrus (DG), in which neuronal proliferation occurs, can also be damaged by ischemia.

Helicase-like transcription factor: a new marker of well-differentiated thyroid cancers.

Background: The preoperative characterization of thyroid nodules is a challenge for the clinicians. Fine-needle aspiration (FNA) is the commonly used pre-operative technique for diagnosis of malignant thyroid tumor. However, many benign lesions, with indeterminate diagnosis following FNA, are referred to surgery.