Publications by authors named "Paula Navarro-Navarro"
Article Synopsis
- Systemic mastocytosis (SM) is a complex disease linked to abnormal mast cells that release mediators affecting the immune environment.
- The study aimed to explore the blood profiles of B-cells, plasma cells, and antibody types in 108 SM patients compared to healthy individuals.
- Results showed increased immature B-cells and elevated IgM and IgD levels in SM patients, alongside decreased plasma cells across various IgH types, with unique immune patterns based on the SM subtype.
Article Synopsis
- Systemic mastocytosis (SM) is a complex disease marked by an increase in abnormal mast cells that can affect the immune system and tumor environment.
- Researchers analyzed blood samples from 115 SM patients and 83 healthy individuals to assess the distribution of various immune cells and their relationship with disease characteristics.
- Findings indicated that SM patients had reduced levels of specific immune cell types compared to healthy controls, with these variations depending on the subtype of SM and certain genetic factors linked to the disease.
Article Synopsis
- The study explores the connection between hereditary alpha-tryptasemia (HAT) and mast cell (MC) disorders, aiming to understand how common HAT is among healthy individuals and patients with different types of MC activation syndromes and mastocytosis.
- The research involved 959 participants, where HAT was found in 4% of healthy donors and higher rates in non-clonal MCAS (29%) and mastocytosis (18%) patients, with more HAT cases in certain mastocytosis subtypes.
- Findings indicate that while HAT is associated with higher serum baseline tryptase levels and a greater occurrence of anaphylaxis in general, it does not necessarily elevate the risk of anaphylaxis severity in
Background: The Red Española de Mastocitosis (Spanish Network on Mastocytosis) score (REMAs) and the National Institutes of Health idiopathic clonal anaphylaxis score (NICAS) were developed for more efficient screening of mast cell (MC) clonality in MC activation syndromes. In a limited idiopathic anaphylaxis case series, the NICAS showed higher accuracy compared with the REMAs.
Objective: To compare the performance of the REMAs against the NICAS in the diagnosis of MC clonality.
Background: Current diagnostic algorithms for systemic mastocytosis (SM) rely on the detection of KITD816V in blood to trigger subsequent bone marrow (BM) investigations.
Methods: Here, we correlated the KITD816V mutational status of paired blood and BM samples from 368 adults diagnosed with mast cell activation syndrome (MCAS) and mastocytosis and determined the potential utility of investigating KITD816V in genomic DNA from blood-purified myeloid cell populations to increase diagnostic sensitivity. In a subset of 69 patients, we further evaluated the kinetics of the KITD816V cell burden during follow-up and its association with disease outcome.
The objective of this study is to describe the alterations occurring during the neurodegenerative process in skin fibroblast cultures from patients. We characterized the oxidative stress, autophagy flux, small ubiquitin-related protein SUMO2/3 levels as well as the mitochondrial function in skin fibroblast cultures from patients. All metabolic and bioenergetic findings were further correlated with gene expression data obtained from RNA sequencing analysis.
View Article and Find Full Text PDFBackground: Mast cells (MC) from systemic mastocytosis (SM) patients release MC mediators that lead to an altered microenvironment with potential consequences on innate immune cells, such as monocytes and dendritic cells (DC). Here we investigated the distribution and functional behaviour of different populations of blood monocytes and DC among distinct diagnostic subtypes of SM.
Methods: Overall, we studied 115 SM patients - 45 bone marrow mastocytosis (BMM), 61 indolent SM (ISM), 9 aggressive SM (ASM)- and 32 healthy donors (HD).