Publications by authors named "Paula Moreno-Gordillo"
The design and preparation of new vectors to transport genetic material and increase the transfection efficiency continue being an important research line. Here, a novel biocompatible sugar-based polymer derived from D-mannitol has been synthesized to be used as a gene material nanocarrier in human (gene transfection) and microalga cells (transformation process). Its low toxicity allows its use in processes with both medical and industrial applications.
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- Fanconi anemia (FA) is a rare genetic disease caused by mutations in certain genes that help fix DNA.
- Cells with FA are very sensitive to certain types of DNA damage and struggle with copying their DNA when it gets blocked.
- The study found that two specific molecules can cause serious DNA damage in FA cells without a protein called FANCD2, but another protein called PARP1 helps protect against this damage.
Metabolically reactive formaldehyde is a genotoxin and a carcinogen. Mice lacking the main formaldehyde-detoxifying gene Adh5 combined with the loss of the Fanconi anemia (FA) DNA repair pathway rapidly succumbed to bone marrow failure (BMF) primarily due to the extensive ablation of the hematopoietic stem cell (HSC) pool. However, the mechanism by which formaldehyde mediates these toxic effects is still unknown.
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