Publications by authors named "Paula Maier"

Article Synopsis
  • This meta-analysis examines how cognitive restructuring affects chronic pain intensity, synthesizing various studies and exploring factors that might influence its effectiveness.
  • After analyzing over 18,000 studies, 11 were selected, revealing a significant overall effect size indicating that cognitive restructuring can meaningfully reduce chronic pain.
  • Findings suggest that the effectiveness of cognitive restructuring varies based on sex and study quality, reinforcing its value in clinical settings, particularly when conducted by professional teams.
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Article Synopsis
  • Researchers aimed to compare eGFR formulas with measured iohexol clearance (iGFR) in children with mild chronic kidney disease (CKD) to see how much those formulas agree or disagree.
  • The study involved 29 children and utilized multiple methods to calculate eGFR, finding that many had conflicting results between different eGFR formulas.
  • The CKiD U25-combined formula was most effective for identifying low GFR in children, but overall, improvements are needed in pediatric eGFR formulas due to significant discrepancies in results.
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Background: Reliable estimates of glomerular filtration rate (GFR) are important in the clinical management of HIV-positive patients. Data on the performance of widely used estimating equations (eGFR) relative to exogenously measured GFR are sparse in this population.

Methods: We evaluated cross-sectional and longitudinal accuracy and bias of eGFR, based on creatinine and cystatin C, relative to disappearance of infused iohexol from plasma (iGFR) in a cohort of participants followed annually for up to 7 years.

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Background: Cystatin C is a key GFR biomarker. Recently, Siemens recalibrated the assay based on certified reference material ERM-DA471/IFCC. The NIH-funded longitudinal chronic kidney disease in children (CKiD) study has > 3000 cystatin C measurements based on a pre-IFCC calibrator provided by Siemens.

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Objective: Renal reserve (RR) measures the increase in glomerular filtration rate (GFR) in response to a protein load; lack of RR could indicate subclinical kidney disease but such a test is not routinely used in clinical practice. The purpose of this study was to compare a meat versus liquid protein load in a cystatin C-based (Cys-C) RR test using cimetidine-inhibited creatinine clearance (Cr Cl) and iohexol infusion clearance (Io Cl) for validation. The design was cross-sectional analysis and the setting was a Clinical Research Center.

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Background: More than two-thirds of the world's HIV-positive individuals live in sub-Saharan Africa, where genetic susceptibility to kidney disease is high and resources for kidney disease screening and antiretroviral therapy (ART) toxicity monitoring are limited. Equations to estimate glomerular filtration rate (GFR) from serum creatinine were derived in Western populations and may be less accurate in this population.

Methods: We compared results from published GFR estimating equations with a direct measure of GFR by iohexol clearance in 99 HIV-infected, ART-naïve Kenyan adults.

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Background: The kidney can increase glomerular filtration rate (GFR) in response to a protein load (renal reserve). In a pilot study of healthy young adults we examined renal reserve using changes in serum cystatin C (cysC).

Methods: Glomerular filtration rate was obtained using iohexol single slope plasma disappearance.

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The Chronic Kidney Disease in Children study is a cohort of about 600 children with chronic kidney disease (CKD) in the United States and Canada. The independent variable for our observations was a measurement of glomerular filtration rate(GFR) by iohexol disappearance (iGFR) at the first two visits 1 year apart and during alternate years thereafter. In a previous report, we had developed GFR estimating equations utilizing serum creatinine, blood urea nitrogen, height, gender, and cystatin C measured by an immunoturbidimetric method; however, the correlation coefficient of cystatin C and GFR(0.

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