Publications by authors named "Paula Kolacki"
Article Synopsis
- The study focused on a new non-invasive prenatal screening (NIPS) test for detecting fetal aneuploidies using advanced sequencing techniques and automated processes.
- Validation of the test involved thousands of maternal plasma samples, leading to effective discrimination between affected (autosomal trisomy) and unaffected pregnancies.
- Positive predictive values (PPVs) were significantly high, at 98% for trisomy 21, 92% for trisomy 18, and 69% for trisomy 13, with improvements noted after addressing false-positive causes.
Objective: We sought to report on laboratory and clinical experience following 6 months of clinical implementation of a single-nucleotide polymorphism-based noninvasive prenatal aneuploidy test in high- and low-risk women.
Study Design: All samples received from March through September 2013 and drawn ≥9 weeks' gestation were included. Samples that passed quality control were analyzed for trisomy 21, trisomy 18, trisomy 13, and monosomy X.