Publications by authors named "Paula J Fedorka-Cray"

Salmonella species are an important cause of systemic and gastrointestinal disease in animals and humans worldwide; they are also increasingly resistant to multiple classes of antimicrobials which may aid in their treatment and control. Salmonella can also be shed asymptomatically. The aim of this study was to survey the U.

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  • Goats can carry foodborne pathogens without showing symptoms, posing risks to human and animal health; this study focused on estimating their prevalence in U.S. goat herds.
  • Of the 3,959 goats examined, 2.3% were found to be positive for specific pathogens, with a higher operation prevalence of 13%; some operations had multiple isolates while others had only one.
  • Resistance to certain antibiotics was observed in the isolates, with 44.9% resistant to tetracycline; factors like access to surface water and the use of antibiotics in feed increased the likelihood of positive findings in operations.
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and species are normal bacteria of the gastrointestinal tract and serve as indicator organisms for the epidemiology and emergence of antimicrobial resistance in their hosts and the environment. Some serovars, including O157:H7, are important human pathogens, although reservoir species such as goats remain asymptomatic. We describe the prevalence and antimicrobial resistance of generic , O157:H7, and species collected from a national surveillance study of goat feces as part of the National Animal Health Monitoring System (NAHMS) Goat 2019 study.

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  • Salmonella species are a significant cause of gastrointestinal disease in both animals, including goats, and humans, ranking among the top five foodborne pathogens in the U.S.
  • This study analyzed fecal samples from goats to assess Salmonella prevalence, antimicrobial resistance, biofilm production, and virulence traits as part of a larger USDA initiative.
  • Results showed a low prevalence of Salmonella (0.7%) in goat feces, with a variety of serotypes present, and most isolates demonstrated susceptibility to antimicrobials while also exhibiting potential virulence traits.
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subsp. serovar Heidelberg has been associated with a broad host range, such as poultry, dairy calves, swine, wild birds, environment, and humans. The continuous evolution of .

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Salmonella enterica is the most common foodborne pathogen worldwide. It causes two types of diseases, a self-limiting gastroenteritis and an invasive, more threatening, infection. Salmonella gastroenteritis is caused by several serotypes and is common worldwide.

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Widespread dissemination of extended-spectrum beta-lactamase (ESBL) () in animals, retail meats, and patients has been reported worldwide except for limited information on small ruminants. Our study focused on the genotypic characterization of ESBL from healthy sheep and their abattoir environment in North Carolina, USA. A total of 113 ESBL isolates from sheep (n = 65) and their abattoir environment (n = 48) were subjected to whole-genome sequencing (WGS).

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International lineages, such as Salmonella Typhimurium sequence type (ST) 19, are most often associated with foodborne diseases and deaths in humans. In this study, we compared the whole-genome sequences of five S. Typhimurium strains belonging to ST19 recovered from clinical human stool samples in North Carolina, United States.

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  • Salmonella Typhimurium and Salmonella Enteritidis have been common causes of salmonellosis outbreaks, but Brazil has seen little research on rare serovars.
  • A study identified and characterized 10 rare Salmonella enterica serovars in Brazil from food sources using whole-genome sequencing and CRISPR genotyping between 2014 and 2016.
  • The analysis revealed the presence of multiple antimicrobial resistance genes in these serovars and emphasized the significance of CRISPR genotyping in understanding the epidemiology of antibiotic-resistant Salmonella in Brazil.
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The increasing prevalence of extended-spectrum beta-lactamase (ESBL)-producing is worrisome. Coordinated efforts to better understand global prevalence and risk factors are needed. Developing lower- and middle-income countries need reliable, readily available, and cost-effective solutions for detecting ESBL to contribute to global surveillance.

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  • Multidrug-resistant (MDR) Salmonella enterica is a major global health concern, as recognized by the World Health Organization, and a study examined 264 isolates from Brazil's poultry and swine sectors over 16 years.* -
  • Whole-genome sequencing showed that multiple international lineages of Salmonella, including notable serovars like S. Typhimurium and S. Kentucky, exhibited both antibiotic resistance and virulence factors.* -
  • Analysis of genetic data revealed specific resistance genes and plasmids, indicating a diverse genetic makeup and persistence of these pathogens in the food production chains.*
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A colistin-resistant Salmonella enterica 4, [5],12:i:- sequence type (ST) 34 harbouring mcr-3.1 was recovered from a patient who travelled to China 2 weeks prior to diarrhoea onset. Genomic analysis revealed the presence of the mcr-3.

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Background: Ceftriaxone resistance in Salmonella is a serious public health threat. Ceftriaxone is commonly used to treat severe Salmonella infections, especially in children. Identifying the sources and drivers of ceftriaxone resistance among nontyphoidal Salmonella is crucial.

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  • The study aimed to assess how common Salmonella spp. is in the feces of cattle from feedlots across the U.S., collecting samples from 68 feedlots in 12 states.
  • Salmonella was found in 9.1% of individual fecal samples and 11.3% of composite samples, with dietary elements influencing its prevalence.
  • Although 32 different Salmonella serotypes were identified, six of them made up nearly 70% of the isolates, and most were sensitive to antimicrobial drugs, with some resistance noted primarily to tetracycline and sulfisoxazole.
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Salmonella Kentucky has become the predominant serovar recovered from broilers slaughtered in the United States, and the prevalence of antimicrobial resistance (AMR) has increased dramatically in this serovar. Relationships between AMR, genotype, and plasmid replicon types were characterized for 600 Salmonella Kentucky isolates recovered from chicken carcasses from 2004 to 2013. Pulsed-field gel electrophoresis cluster analysis revealed 112 unique types sharing 79% similarity.

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Salmonella is a major cause of foodborne illness and can cause clinical disease in animals. Understanding the on-farm ecology of Salmonella will be helpful in decreasing the risk of foodborne transmission. An objective of this study was to determine the prevalence of Salmonella among fecal samples collected on sheep operations in the United States.

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Salmonella enterica is one of the most common causes of bacterial foodborne illness in the United States. Although most Salmonella infections are self-limiting, antimicrobial treatment of invasive salmonellosis is critical. The primary antimicrobial treatment options include fluoroquinolones or extended-spectrum cephalosporins, and resistance to these antimicrobial drugs may complicate treatment.

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Escherichia albertii is a recently described species that has been associated with gastroenteritis in humans and with healthy and ill birds. Most recently, it has been identified as the causative agent in a food-borne outbreak in Japan. The distribution and clinical importance of E.

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  • Salmonella serotype Typhimurium is a significant cause of foodborne illnesses, making it hard to trace infection sources due to its presence in various agricultural environments.
  • Extended-spectrum cephalosporins (ESC), like ceftriaxone and amoxicillin/clavulanic acid, are commonly used treatments for complicated Salmonella infections, with resistance primarily linked to specific blaCMY plasmids.
  • This study analyzes the differences in blaCMY plasmids and antimicrobial resistance patterns among Salmonella isolates from retail meat, food animals, and humans to potentially determine the source of infections when outbreaks occur.
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