Publications by authors named "Paula C Rangel"
Article Synopsis
- Clostridium difficile infection (CDI) poses a significant public health risk, with few prevention methods available.* -
- Researchers developed a multivalent mRNA-lipid nanoparticle vaccine that stimulates strong immune responses in various animal models, unaffected by gut microbiota changes.* -
- The vaccine effectively protects mice from severe CDI and enhances the elimination of harmful bacteria from the gut, highlighting mRNA-LNP technology as a potential new treatment avenue.*
Enteric pathogens are exposed to a dynamic polymicrobial environment in the gastrointestinal tract. This microbial community has been shown to be important during infection, but there are few examples illustrating how microbial interactions can influence the virulence of invading pathogens. Here we show that expansion of a group of antibiotic-resistant, opportunistic pathogens in the gut-the enterococci-enhances the fitness and pathogenesis of Clostridioides difficile.
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