Publications by authors named "Paula Beattie"
Article Synopsis
- A study was conducted to reach a consensus on interpreting skin prick tests (SPT) and dietary history related to food allergies in children under two with atopic dermatitis (AD).
- Fourteen healthcare professionals participated in a modified Delphi study, discussing symptoms related to allergies and reaching agreements on allergen categorization and dietary advice.
- The findings led to standardized recommendations for managing common food allergies like cow's milk, hen's egg, wheat, and soy, aiming to improve clinician education and decision-making.
Article Synopsis
- The study compares the real-world effectiveness and safety of three treatments for atopic dermatitis: dupilumab, ciclosporin (CyA), and methotrexate (MTX), using data from the A-STAR register in the UK and Ireland.
- It involved 488 patients (adults and children) and measured treatment outcomes like the Eczema Area and Severity Index (EASI) and quality of life scales over 12 months.
- Results showed that dupilumab and CyA led to faster improvements in skin severity scores and overall patient outcomes compared to MTX, indicating dupilumab is an effective option in managing atopic dermatitis.
Article Synopsis
- A study compared the safety and effectiveness of ciclosporin (CyA) and methotrexate (MTX) in treating severe atopic dermatitis (AD) in children and young people aged 2-16 who didn't respond to topical treatments.
- Cyclists showed more significant improvement at the 12-week mark, with more patients achieving at least a 50% improvement in their AD scores compared to those on MTX.
- However, by the 60-week follow-up, MTX demonstrated better long-term outcomes, indicating its potential superiority beyond the initial treatment period.
Background: Psychological and mental health difficulties are common in children and young people (CYP) living with skin conditions and can have a profound impact on wellbeing. There is limited guidance on how best to assess and support the mental health of this population, who are at risk of poor health outcomes.
Objectives: To provide consensus-based recommendations on the assessment and monitoring of and support for mental health difficulties in CYP with skin conditions (affecting the skin, hair and nails); to address practical clinical implementation questions relating to consensus guidance; and to provide audit and research recommendations.
Progressive osseous heteroplasia (POH) is a rare genetic disorder characterised by progressive heterotopic ossification (HO) within the skin and subcutaneous tissues. The condition is caused by heterozygous inactivating mutations of the gene and usually presents in infancy. We describe the case of a white male ex-preterm who was first referred because of subcutaneous calcium deposits along the right arm after extravasation of parenteral nutrition.
View Article and Find Full Text PDFBackground: Few data exist on differences in treatment effectiveness and safety in atopic dermatitis patients of different skin types.
Objective: To investigate treatment outcomes of dupilumab, methotrexate, and ciclosporin, and morphological phenotypes in atopic dermatitis patients, stratified by Fitzpatrick skin type.
Methods: In an observational prospective cohort study, pooling data from the Dutch TREAT (TREatment of ATopic eczema) NL (treatregister.
The phenotypic spectrum of genodermatoses is continuously expanding. Three siblings were referred because of a highly unusual phenotype comprising alopecia, dystrophic nails, palmoplantar keratoderma and trauma-induced skin blistering. Whole-exome sequencing analysis identified a heterozygous large genomic alteration of around 116 0000 bp resulting in the deletion of the KRT9, KRT14, KRT15, KRT16 and KRT19 genes, as well as part of KRT17.
View Article and Find Full Text PDFAtopic dermatitis (AD) is the most common dermatological disease of childhood. Many children with AD have asthma and AD shares regions of genetic linkage with psoriasis, another chronic inflammatory skin disease. We present here a genome-wide association study (GWAS) of childhood-onset AD in 1563 European cases with known asthma status and 4054 European controls.
View Article and Find Full Text PDFAs phototoxic skin reactions caused by psoralen are induced by wavelengths within the UVA1 spectrum, we assessed the potential of the small amount of psoralen in a normal diet to provoke phototoxicity in volunteers with skin types I and II. Threshold erythema was unaffected by ingestion of a 200-g portion of parsnip.
View Article and Find Full Text PDFObjective: To determine the time course and dose-response characteristics of UV-A1 erythema in the Tayside region of Scotland.
Design: Adult volunteers (skin types I and II [n = 13] and III and IV [n = 11]) were exposed to geometric dose series of UV-A1 irradiation from a high-output source on photoprotected lower back and inner forearm skin.
Setting: Photobiology unit in a university hospital.
Background: As little has been published on the course of idiopathic solar urticaria (SU) patients cannot receive comprehensive prognostic advice.
Objective: To determine the prognosis and photobiological characteristics of idiopathic SU.
Design: Historical cohort study, with inception cohort followed up from time of diagnosis.