Publications by authors named "Paula Assis Queiroz"
Article Synopsis
- Polymyxin B (PMB) is currently one of the few options to treat serious infections caused by drug-resistant Gram-negative bacteria, but resistance to PMB is emerging.
- This study tests several chemical compounds, including 3,5-dinitrobenzoic acid derivatives and isoniazid-acylhydrazones, to see if they can enhance the effectiveness of PMB against resistant bacteria.
- Results showed that DNH derivatives significantly improved PMB's activity against 80% of tested strains, allowing for effective treatment at much lower concentrations than PMB alone, suggesting they could be valuable in fighting resistant infections.
Due to the significant shortage of therapeutic options for carbapenem-resistant (CRE) infections, new drugs or therapeutic combinations are urgently required. We show in this study that (-)-camphene-based thiosemicarbazide (TSC) may act synergistically with polymyxin B (PMB) against CRE, rescuing the activity of this antimicrobial. With the specific aim of a better molecular understanding of this effect caused by the presence of TSC, theoretical calculations were also performed in this study.
View Article and Find Full Text PDFAdhesion and biofilm formation in artificial saliva and susceptibility of yeasts isolated from chronic kidney patients undergoing haemodialysis.
J Med Microbiol
September 2015
Yeasts of the genera Candida and Saccharomyces are opportunist pathogens and cause oral lesions, especially in immunocompromised patients. This study assessed yeasts isolated from chronic kidney patients undergoing haemodialysis for their adhesion capacity, biofilm formation and susceptibility to antifungal agents. Ten isolates of Candida spp.
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