Publications by authors named "Paula Aguilera Peiro"

Background: The European Photopatch Testing Baseline Series (EPTBS) was published in 2013. However, limited data exist regarding the real-world clinical application of the EPTBS.

Objectives: This study aims to describe the photopatch test experience with the EPTBS over 11 years at a tertiary hospital in Spain.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the long-term effectiveness and safety of givosiran in treating acute hepatic porphyria, a condition characterized by toxic levels of heme precursors.
  • It involved an interim analysis of the ENVISION study, where patients either received givosiran or a placebo for six months, followed by an open-label extension.
  • Results showed that givosiran significantly reduced attack frequency, need for hemin treatment, and daily pain severity, while also improving patients' quality of life with an acceptable safety profile.
View Article and Find Full Text PDF

Background: Up-regulation of hepatic delta-aminolevulinic acid synthase 1 (ALAS1), with resultant accumulation of delta-aminolevulinic acid (ALA) and porphobilinogen, is central to the pathogenesis of acute attacks and chronic symptoms in acute hepatic porphyria. Givosiran, an RNA interference therapy, inhibits ALAS1 expression.

Methods: In this double-blind, placebo-controlled, phase 3 trial, we randomly assigned symptomatic patients with acute hepatic porphyria to receive either subcutaneous givosiran (2.

View Article and Find Full Text PDF

Background: Intralesional injection of Candida antigen appears to be an effective alternative for the treatment of warts.

Aim: To determine the efficacy and safety of this treatment.

Methods: We retrospectively reviewed records of all children who received intralesional injection of Candida antigen at our center from January 2008 to July 2013.

View Article and Find Full Text PDF