Publications by authors named "Paul Y Jiang"
Article Synopsis
- Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) are rare conditions causing severe skin reactions to sunlight, and afamelanotide is the only approved treatment that enhances light tolerance and quality of life (QoL).
- A study conducted at Massachusetts General Hospital evaluated 29 adults who received afamelanotide, showing that patients experienced significant increases in time before phototoxic symptoms appeared after sunlight exposure, indicating improved light tolerance.
- Despite these benefits in light tolerance and QoL, the treatment did not result in improvements in laboratory markers of protoporphyria or liver function.
Int J Dermatol
November 2024
Article Synopsis
- Erythropoietic protoporphyria (EPP) causes painful sensitivity to light, impacting patients' quality of life, and researchers aimed to create a wearable device to measure light exposure.
- A pilot study involved five EPP patients using two different light dosimeters over three weeks to assess their light exposure levels.
- Findings indicated that increased exposure to blue light significantly raised the risk of symptoms, with the wristband device showing a predictive accuracy of 78%, suggesting it could effectively help manage EPP symptoms.
