Publications by authors named "Paul W Mola"

This work reports the first CMOS molecular electronics chip. It is configured as a biosensor, where the primary sensing element is a single molecule "molecular wire" consisting of a ∼100 GΩ, 25 nm long alpha-helical peptide integrated into a current monitoring circuit. The engineered peptide contains a central conjugation site for attachment of various probe molecules, such as DNA, proteins, enzymes, or antibodies, which program the biosensor to detect interactions with a specific target molecule.

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Article Synopsis
  • - The text discusses a novel molecular electronics chip that utilizes single molecules as general-purpose sensors, allowing for ultra-miniaturized electronic circuits.
  • - The device features a semiconductor chip with an array of synthetic molecular wires connected to nanoelectrodes, enabling real-time monitoring of molecular interactions at high speeds (1,000 frames per second).
  • - It demonstrates the ability to measure single-molecule interactions, such as those involving DNA, antibodies, and enzymes, with exceptional sensitivity and without needing labels, which can enhance various applications in biosensing and diagnostics.
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Cells undergo M phase arrest in response to stresses like UV irradiation or DNA damage. Stress-activated protein kinase (SAPK, also known as c-Jun N-terminal kinase, JNK) is activated by such stress stimuli. We addressed the potential effects of SAPK activation on cell cycle regulatory proteins.

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