Publications by authors named "Paul Vergnaud"
Chronic kidney disease (CKD) is a global health problem affecting almost 15% of the population worldwide. After renal injury, there is a nephron loss and remaining nephrons ensure the glomerular filtration rate (GFR) with compensatory hyperplasia and hypertrophy: This is called the nephron reduction. After nephron reduction, renal function will gradually decline and lead to chronic end-stage renal failure.
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- Renal arcuate vein thrombosis (RAVT) is a rare condition that can cause kidney problems in young adults, but we don’t fully understand how often it happens or why it occurs.
- Researchers looked at five young patients with RAVT found during kidney tests, and they noticed that four of them used a lot of pain medication called NSAIDs, which might be linked to the problem.
- They also found signs of a virus called SARS-CoV-2 in one patient’s kidney, suggesting that this virus could harm blood vessels in the kidneys, making the situation worse.
Acute kidney injury is one of the most important complications in patients with COVID-19 and is considered a negative prognostic factor with respect to patient survival. The occurrence of direct infection of the kidney by SARS-CoV-2, and its contribution to the renal deterioration process, remain controversial issues. By studying 32 renal biopsies from patients with COVID-19, we verified that the major pathological feature of COVID-19 is acute tubular injury (ATI).
View Article and Find Full Text PDFKidney mass and function are sexually determined, but the cellular events and the molecular mechanisms involved in this dimorphism are poorly characterized. By combining female and male mice with castration/replacement experiments, we showed that male mice exhibited kidney overgrowth from five weeks of age. This effect was organ specific, since liver and heart weight were comparable between males and females, regardless of age.
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