Publications by authors named "Paul Vaughan"

Background: SARS-CoV-2 has challenged health service provision worldwide. This work evaluates safe surgical pathways and standard operating procedures implemented in the high volume, global city of London during the first wave of SARS-CoV-2 infection. We also assess the safety of minimally invasive surgery(MIS) for anatomical lung resection.

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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus primarily affecting the respiratory system, was initially diagnosed in Wuhan, China, in late 2019. Identified as coronavirus disease 2019 (COVID-19) by the World Health Organization, the virus rapidly became a global pandemic. The effects on health care worldwide were unprecedented as countries adapted services to treat masses of critically ill patients.

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Objectives: Taxonomy of injuries involving the costal margin is poorly described and surgical management varies. These injuries, though commonly caused by trauma, may also occur spontaneously, in association with coughing or sneezing, and can be severe. Our goal was to describe our experience using sequential segmental analysis of computed tomographic (CT) scans to perform accurate assessment of injuries around the costal margin.

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Lung volume reduction surgery (LVRS) has been shown to be beneficial in patients with chronic obstructive pulmonary disease, but there is low uptake, partly due to perceived concerns of high operative mortality. We aimed to develop an individualised risk score following LVRS.This was a cohort study of patients undergoing LVRS.

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The nursing profession prides itself on its ability to reflect on practice to improve patient care. Yet we have seen a number of high-profile cases in recent years where care has not been provided at the level you would expect.

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Pulmonary carcinoid and pulmonary lymphoma are both rare cancers and are seldom seen together. Cases have been reported of their coexistence in the gastrointestinal tract, but our literature searches only found a single case of their coexistence in the lung. We discuss our case as well as the literature to try to find a connection and explanation for this occurrence.

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A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was whether endobronchial valves improve outcomes in patients with severe emphysema. Eighty-seven papers were found using the reported search, of which seven represented the best evidence to answer the clinical question.

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The eponymous Carney triad reported the association of gastric leiomyosarcoma, also known as a gastrointestinal stromal tumor, extra-adrenal paraganglioma and pulmonary chondromata. Subsequently, Carney and Stratakis distinguished the inherited gastrointestinal stromal tumor with paraganglioma syndrome from the classical Carney Triad as an autosomal dominant condition in adult patients. This combination of gastrointestinal stromal tumor and cardiac paragangliomata in a child is almost unique.

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Background: Although an atrial myxoma is the commonest cardiac tumor, it is still relatively rare, with an annual incidence of approximately 0.5 per million. In our unit, which performs 1000 major cardiac procedures per year, this equates to approximately 3 patients annually.

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Endobronchial valves are increasingly used as a treatment modality as a less invasive alternative to lung volume reduction surgery in patients with severe emphysema. Endobronchial valves have also been used to treat patients with persistent pulmonary air leaks and those with bronchopleural fistulae. We report a case of a 61-year-old male with severe bullous emphysema.

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Article Synopsis
  • Penetrating aortic ulcers are more commonly found in the descending thoracic and abdominal aorta, but are rare in the aortic arch and its major branches.
  • The case involves a 71-year-old woman who had multiple penetrating aortic ulcers that impacted both her aortic arch and the brachiocephalic artery.
  • The report highlights the successful treatment of her condition.
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Assisted venous drainage (AVD) is considered an essential component of the cardiopulmonary bypass (CPB) circuit for minimal access aortic valve replacement (mAVR). The rationale/necessity for AVD in every patient has not been fully elucidated. Data from consecutive patients undergoing isolated first-time mAVR by a single surgeon from March 2006 to October 2008 was prospectively collected.

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A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether biventricular pacing provides a superior cardiac output compared to univentricular pacing wires after cardiac surgery. Using the reported search, 439 papers were found from which 13 papers represented the best evidence on the subject.

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The RCN's new healthcare assistant (HCA) adviser Paul Vaughan answers questions about HCAs' role, career, responsibilities and value.

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The development of novel scaffolds will be an important aspect in future success of tissue engineering. Scaffolds will preferably contain information that directs the cellular content of constructs so that the new tissue that is formed is closely aligned in structure, composition and function to the target natural tissue. One way of approaching this will be the development of novel protein-based constructs that contain one or more repeats of functional elements derived from various proteins.

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Objective: Radiosurgical ablation of the mesial temporal lobe structures can be used in the treatment of intractable temporal lobe epilepsy associated with mesial temporal sclerosis. In this study, we analyzed the magnetic resonance imaging (MRI) and spectroscopic changes that follow the treatment and report the clinical sequelae of the procedure.

Methods: Eight patients (five men and three women; age, 38 +/- 15 yr [mean +/- standard deviation]) with mesial temporal sclerosis were treated with radiosurgical amygdalohippocampectomy (25 Gy to the 50% isodose region with a mean target volume of 6.

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The 'year of the HCA'.

Nurs Manag (Harrow)

February 2008

Around this time last year, there were said to be about 40,000 managers in the NHS, and questions were asked in the media about what they all did. More recently, managers at several NHS trusts have been blamed for losing patient records.

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Objectives: LVRS is thought to result in significant improvements in BMI. Patients with a higher BMI at the time of diagnosis of COPD are known to have better survival, and those with a low BMI prior to LVRS have significantly worse perioperative morbidity. We aimed to assess the influence of BMI on the outcome of LVRS in our own experience.

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One of the earliest indications for Gamma Knife treatment, radiosurgery for cerebral arteriovenous malformations, has stood the test of time. While initially only the ideal cases (small, compact nidus in a non-eloquent site) were chosen, increasingly larger, more complex AVMs were treated. Combination treatment with embolisation and surgery enables most lesions to be treated with success and remarkably low complication rate.

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Article Synopsis
  • Anatomical lobectomy can be performed safely in patients with bronchial carcinoma and severe heterogeneous emphysema, challenging previous operability guidelines.
  • A study of 118 patients showed that those with severe emphysema had a lower five-year survival rate (35%) compared to those without emphysema (65%), although postoperative mortality rates were similar.
  • Despite limited long-term survival due to physiological issues, lobectomy remains the best treatment option for high-risk patients with stage I lung cancer, justifying its use in selected cases.
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Article Synopsis
  • A study aimed to assess the effectiveness of standard lobectomy for patients with non-small cell lung cancer and severe emphysema, comparing it to conventional lung volume reduction surgery.
  • Researchers conducted a retrospective review of 34 patients who underwent lobectomy, noting that their postoperative lung function was better than expected due to the removal of diseased lung tissue.
  • The analysis revealed that lobectomy patients were older and had better lung function than those who received lung volume reduction surgery, suggesting potential advantages for lobectomy in similar cases.
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Article Synopsis
  • Notaden bennetti frogs produce a unique adhesive known as "frog glue" when threatened, which can stick to surfaces even when wet and shows high tensile and shear strength.
  • The glue is primarily composed of proteins with specific amino acid profiles, and its most abundant protein is crucial for its structure.
  • Analysis reveals the glue's extraordinary properties, including resilience and elastic modulus, and suggests that it self-assembles without the need for covalent cross-linking to solidify.
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