Publications by authors named "Paul V Andrew"
Article Synopsis
- - The study investigated the effects of a new zinc lactobionate emollient cream on the skin barrier of patients with atopic dermatitis (AD), aiming to lower elevated skin surface pH which can harm skin function.
- - In a controlled trial with 23 adult participants, the cream significantly decreased skin surface pH and transepidermal water loss (TEWL) over 56 days, indicating improved skin barrier integrity compared to a control cream.
- - Results suggest that maintaining an acidic skin pH and providing necessary lipids can enhance skin health and alleviate symptoms of AD by reducing sensitivity to irritants and allergens.
Background: Eczema (atopic dermatitis; AD) is a very common itchy skin condition affecting 1 in 5 children and up to 1 in 10 adults worldwide. The skin of eczema sufferers is prone to redness, irritation and dryness because it does not form an effective barrier, i.e.
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- Patients with atopic dermatitis show disrupted skin barrier function due to abnormal lipid levels, leading to increased sensitivity to irritants.
- A study tested a cream containing ceramides, triglycerides, and cholesterol on 34 adults with eczema-prone skin to evaluate its effectiveness in improving skin barrier integrity.
- Results indicated that the test cream significantly enhanced skin hydration and barrier function, reduced sensitivity to irritants, and was more effective than a standard emollient for managing dry, sensitive skin.
Introduction: The replenishment of skin lipids depleted in the dry skin state is a desirable therapeutic target to restore skin moisturization; however, there is limited evidence demonstrating the success of this approach through the use of topical emollients. The purpose of this study was to provide evidence of the benefits of a cream and equivalent lotion containing skin lipids in a multi-vesicular emulsion for the management of dry skin. The hypothesis was that the test cream and test lotion could sustain skin moisturization for longer than traditional emollients by sustainably delivering skin lipids.
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