Publications by authors named "Paul Tobin"

Article Synopsis
  • Researchers used a special imaging technique called two-photon optical imaging to study how cervical lymphatic vessels (cLVs) drain cerebrospinal fluid (CSF) in live mice, revealing that contraction of the vessel walls is the main driving force of this flow.* -
  • They found that in older mice, the frequency of these contractions and the speed of fluid flow decreased, linked to lower levels of smooth muscle actin.* -
  • By applying prostaglandin F to aged mice, the researchers were able to enhance muscle contraction and improve CSF drainage, suggesting that boosting cLV function could help clear waste from the brain in aging individuals.*
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Background: Spinal cord injury is a condition that adversely impacts employment and economic stability. The Kessler Foundation National Employment and Disability Survey (KFNEDS) was developed to understand the experience of striving to work among persons with disabilities. However, this survey was not intended to capture the employment experiences of veterans living with spinal cord injury.

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In everyday conversation, we often use indirect replies to save face of our interlocutor (e.g., "Your paper does have room for improvement").

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Background: An estimated 42,000 people currently living with chronic spinal cord injury (SCI) are veterans. SCI was a common combat-related injury in the World Wars and Vietnam era and now affects more than 11% of military personnel injured in Operation Iraqi Freedom and Operation Enduring Freedom. The Veterans Benefits Administration primarily offers financial compensation for disabilities sustained or re-aggravated during military service, called service-connected disability compensation.

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A Porphyra dioica protein extract was enzymatically hydrolysed and then fractionated using semi-preparative reverse-phase high performance chromatography. The hydrolysate and its fractions were tested for their oxygen radical absorbance capacity (ORAC) along with their angiotensin converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) inhibitory activities. The most potent fraction was analysed by liquid chromatography mass spectrometry.

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The National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances (NAC/AEGL) was created to develop guideline levels for short-term exposures to airborne concentrations for approximately 400-500 high priority, acutely hazardous substances. The program should be completed within the next 10 years. These Acute Exposure Guideline Levels (AEGLs) are being applied to a wide range of planning, response, and prevention applications both within the United States and abroad.

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