Publications by authors named "Paul Tarrant"
TET2 is a methylcytosine dioxygenase that is frequently mutated in myeloid malignancies, notably myelodysplasia and acute myeloid leukemia. TET2 catalyses the conversion of 5'-methylcytosine to 5'-hydroxymethylcytosine within DNA and has been implicated in the process of genomic demethylation. However, the mechanism by which TET2 loss of function results in hematopoietic dysplasia and leukemogenesis is poorly understood.
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- The blood system relies on a small group of haematopoietic stem cells (HSCs) that generate blood cells continuously throughout life, with megakaryocytes in bone marrow producing platelets essential for preventing bleeding.
- Current research aims to understand different HSC subsets and how they relate to blood cell production, specifically focusing on those biased toward generating lymphoid or myeloid blood cells.
- The study identifies a unique subset of HSCs that are particularly geared towards producing platelets, highlighting the importance of thrombopoietin in their maintenance and suggesting new therapy approaches to boost platelet production after treatments like chemotherapy.