Publications by authors named "Paul T Austin"
Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through 'viral mimicry' responses. Paradoxically, cancer-initiating events also facilitate transcription of repetitive elements. Contributions of repetitive element transcription towards cancer initiation, and the mechanisms by which cancer cells evade lethal viral mimicry responses during tumor initiation remain poorly understood.
View Article and Find Full Text PDFNovel therapies are urgently needed for ovarian cancer, the deadliest gynecologic malignancy. Ovarian cancer has thus far been refractory to immunotherapies that stimulate the host immune system to recognize and kill cancer cells. This may be because of a suppressive tumor immune microenvironment and lack of recruitment and activation of immune cells that kill cancer cells.
View Article and Find Full Text PDFEffects of elevated root zone (RZ) CO(2) and air temperature on photosynthesis, productivity, nitrate (NO(3)(-)), and total reduced nitrogen (N) content in aeroponically grown lettuce plants were studied. Three weeks after transplanting, four different RZ [CO(2)] concentrations [ambient (360 ppm) and elevated concentrations of 2000, 10,000, and 50,000 ppm] were imposed on plants grown at two air temperature regimes of 28 degrees C/22 degrees C (day/night) and 36 degrees C/30 degrees C. Photosynthetic CO(2) assimilation (A) and stomatal conductance (g(s)) increased with increasing photosynthetically active radiation (PAR).
View Article and Find Full Text PDFArticle Synopsis
- HTLL treatment on the 35S:PAP1 Arabidopsis thaliana leads to a reversible decrease in red color, indicating the involvement of other regulators in anthocyanin production besides the PAP1 gene.
- Various analytical methods revealed changes in anthocyanin levels and gene expression, showing that certain anthocyanins were reduced while others increased, pointing to a degradation process rather than production.
- Gene expression analysis after HTLL treatment showed a down-regulation of anthocyanin biosynthesis genes and an increase in potential repressors, highlighting HTLL as a useful tool for studying anthocyanin breakdown and the genes that control it environmentally.
Article Synopsis
- The study investigated how eight different clonal Actinidia rootstocks impact the development of scions—specifically, yellow kiwifruit—by examining shoot types and leaf area index (LAI).
- It classified axillary shoots from the scion as short, medium, or long and found that scions on low-vigor rootstocks produced fewer leaves and had more terminated shoots compared to those on vigorous rootstocks.
- The research concluded that while all rootstocks consistently affected shoot development, low-vigor rootstocks led to a higher proportion of slow-growing shoots, which terminated earlier in the season, thereby influencing future growth patterns.