Publications by authors named "Paul Sinel-Boucher"
Importance: Oral endocrine treatments have been shown to be effective when carefully adhered to. However, in patients with early breast cancer, adherence challenges are notable, with 17% experiencing nonpersistence and 41% nonadherence at least once.
Objective: To model the persistence of and adherence to oral anticancer treatment of a patient with localized breast cancer.
Article Synopsis
- A study analyzed the impact of resuming CPAP therapy after initial termination in patients with obstructive sleep apnea (OSA) and found that 26% of individuals resumed CPAP within a year, with a majority continuing for at least another year.
- Significant factors influencing CPAP continuation included being male, having hypertension, and receiving a prescription from a pulmonologist.
- Patients who resumed and continued CPAP therapy had a 38% lower risk of all-cause mortality compared to those who discontinued again, highlighting the importance of offering a second chance for CPAP therapy to those who initially struggle.
Background: Randomized controlled trials have failed to demonstrate an effect of CPAP therapy on mortality. However, these studies have a number of important limitations, including low CPAP adherence, patient selection, and a small number of mortality events.
Research Question: What are the effects of CPAP therapy termination in the first year on all-cause mortality in patients with OSA from the Nationwide Claims Data Lake for Sleep Apnea study?
Study Design And Methods: Data from the Système National des Données de Santé (SNDS) database, the French national health insurance reimbursement system, for all new CPAP users ≥ 18 years of age were analyzed.