Publications by authors named "Paul S Nestadt"
Article Synopsis
- The study focuses on the high prevalence of obsessive-compulsive disorder (OCD) among pregnant and postpartum women and emphasizes the importance of efficient screening tools for early detection in perinatal care.
- Researchers evaluated the 4-item Obsessive Compulsive Inventory (OCI-4) for its reliability, validity, and diagnostic sensitivity through assessments at various stages of pregnancy and postpartum.
- Results indicate that the OCI-4 is a reliable and effective screening tool for identifying OCD symptoms in perinatal women, with a specific score of 3 providing optimal sensitivity and specificity for detection.
Article Synopsis
- Obsessive-compulsive disorder (OCD) affects about 1% of people and has a strong genetic component, but previous studies have not fully explained its genetic causes or biological mechanisms.
- A large genome-wide association study (GWAS) analyzed data from over 53,000 OCD cases and over 2 million control participants, identifying 30 significant genetic markers related to OCD and suggesting a 6.7% heritability from SNPs.
- The research also found 249 candidate risk genes linked to OCD, particularly in specific brain regions, and showed genetic correlations with various psychiatric disorders, laying the groundwork for further studies and potential treatments.
Background: Although general anxiety has increased markedly since the onset of the COVID-19 pandemic, little has been reported about the demographic distribution of COVID-19 related worry, its relationship with psychological features, and its association with depression symptoms in the United States (US).
Methods: 2117 participants, selected to represent the age, gender, and race/ethnic distributions of the US population, completed an online survey. Analysis of variance and correlation analyses were used to assess relationships between the COVID-19 related worry score and demographic characteristics, past psychiatric diagnoses, personality dimensions, and current psychological symptoms.
Importance: The prevalence of internalizing problems among US adolescents has risen in the past decade. The extent to which concerns about school violence or shootings are associated with risk of internalizing problems is unknown.
Objective: To examine the prospective association of concern, worry, and stress related to school violence or shootings with internalizing problems and to examine sex and racial and ethnic differences in the magnitude of the associations.
Background: During the COVID-19 pandemic, many Americans have experienced mental distress, which may be partially characterized by a rise in mental illnesses. However, COVID-19 specific psychological distress may also be separate from diagnosable conditions, a distinction that has not been well established in the context of the pandemic.
Methods: Data came from an online survey of US adults collected in March 2020.