Single-Use Autoinjector Functionality And Reliability For At-Home Administration Of Benralizumab For Patients With Severe Asthma: GRECO Trial Results.

Purpose: Accessorized prefilled syringes (APFS) have demonstrated functionality and reliability for subcutaneous (SC) delivery, including self-administration, of benralizumab 30 mg in the clinic or at home. The multicenter, open-label GRECO study (NCT02918071) assessed functionality and reliability of a single-use autoinjector (AI) for at-home benralizumab administration by patients or their caregivers.

Patients And Methods: Adults with severe asthma received benralizumab SC injections at the study site at Weeks 0, 4, and 8.

Characterization of the initial level and migration of silicone oil lubricant in empty prefilled syringes for biologics using infrared spectroscopy.

Unlabelled: Glass prefillable syringes are lubricated with silicone oil to ensure functionality and a consistent injection for the end user. If excessive silicone is applied, droplets could potentially result in aggregation of sensitive biopharmaceuticals or clouding of the solution. Therefore, monitoring and optimization of the applied silicone layer is critical for prefilled syringe development.

Constructing cerium supramolecular wheels and encapsulating uranium with a Schiff-base calixpyrrole ligand.

Trinuclear, supramolecular wheel structures are formed spontaneously from the metallation of a Schiff-base-pyrrole macrocycle by Ce(3+) cations, while the related actinide U(3+) cation is instead oxidised to U(4+) and encapsulated by the macrocyclic framework.

Complexes of Triamidoamines with the Early Actinides. Synthetic Routes to Monomeric Compounds of Tetravalent Uranium and Thorium Containing Halide and Amide Ligands.

The reaction of the lithiated triamidoamine [Li(3)(NN'(3))(THF)(3)] [NN'(3) = N(CH(2)CH(2)NSiMe(2)Bu(t))(3)] with AnCl(4) (An = U, Th) followed by sublimation gives monomeric [An(NN'(3))Cl]. Reaction of these complexes with SiMe(3)X (X = Br, I) gives [An(NN'(3))X]. The amido derivatives [An(NN'(3))(NEt(2))] are prepared from H(3)(NN'(3)) and [U(NEt(2))(4)] and from [Th(NN'(3))Cl] and [Li(NEt(2))].

Alkoxide and Aryloxide Derivatives of a (Triamidoamine)uranium Complex.

The (triamidoamine)uranium chloride complex [{U(NN(3))(&mgr;-Cl)}(2)] [NN(3) = N(CH(2)CH(2)NSiMe(3))(3)] reacts with alkali metal alkoxides and aryloxides to give a range of complexes [U(NN(3))(OR)] (R = Bu(t), t-C(4)F(9), Ph, 2,6-Bu(t)(2)-4-MeC(6)H(2)). Crystallographic investigations (including the molecular structure of the perfluoro-tert-butoxido derivative [U(NN(3))(O-t-C(4)F(9))]), molecular weight determinations, and NMR spectroscopic data are consistent with these molecules being monomeric with a 3-fold symmetric arrangement of the triamidoamine fragment. The three turquoise ate complexes [U(NN(3))(OR)(OR')Li(THF)(n)()] (R, R' = Bu(t) or Ph), are prepared by reaction of the corresponding uranium alkoxides with lithium phenoxide or tert-butoxide.