Wegener's granulomatosis.

The immunopathologic disease, Wegener's granulomatosis, presents a challenge to the anesthesiologist due to multisystem involvement resulting in potential abnormalities of the airway, respiratory, circulatory, renal, and central/peripheral nervous systems. It is a systemic vasculitis of small, medium and occasional large arterial involvement. A familiarity with the proper approach to perioperative management is essential.

MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner.

MRGX is a novel transcription factor that is a member of the mortality factor 4 (MORF4)-related gene family. MRG15, a closely related family member, is in a complex with the retinoblastoma tumor suppressor protein Rb and activates the B-myb promoter, which is tightly controlled by Rb/E2F through the E2F binding site. In this study we investigated the effect of MRGX on the B-myb promoter.