Publications by authors named "Paul Petitgas"

Introduction: Temocillin is a semi-synthetic β-lactam with a narrow spectrum but high stability against hydrolysis by β-lactamases, including AmpC. Despite its favourable properties, data regarding its clinical value in the treatment of AmpC β-lactamase-producing Enterobacterales (ABPE) infections are scarce. Most recent guidelines do not include temocillin in the therapeutic strategy for ABPE infection.

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Article Synopsis
  • Paradoxical reaction (PR) and immune reconstitution inflammatory syndrome (IRIS) are common complications in tuberculosis treatment, often requiring corticosteroids for severe cases, especially those affecting the nervous system.
  • In a study of four patients and a literature review of 20 more, most of the affected individuals were middle-aged, with a significant number being immunocompromised prior to their tuberculosis diagnosis.
  • TNF-α antagonists, specifically infliximab, thalidomide, and adalimumab, were used as additional treatment for severe cases of PR or IRIS, leading to improvement in all patients, despite some experiencing neurological issues and related adverse effects from the treatment.
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Purpose: Data on encephalitis in elderly patients are scarce. We aimed to describe the characteristics, aetiologies, management, and outcome of encephalitis in patients older than 65 years.

Methods: We performed an ancillary study of ENCEIF, a prospective cohort that enrolled all cases of encephalitis managed in 46 clinical sites in France during years 2016-2019.

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Background: Checkpoints inhibitors (CPIs) are increasingly used for the treatment of several malignancies. The most common side effects are Immune Related Adverse Events, while infectious complications are rare, especially cerebral nocardiosis.

Case Presentation: Here, we report the first clinical case of a cerebral nocardiosis revealed after seizure in a patient treated by pembrolizumab for a metastatic lung cancer, in the absence of any additional immunosuppressive therapy or risk factors for cerebral nocardiosis.

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Objectives: To provide an overview of the spectrum, characteristics and outcomes of neurologic manifestations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Methods: We conducted a single-centre retrospective study during the French coronavirus disease 2019 (COVID-19) epidemic in March-April 2020. All COVID-19 patients with de novo neurologic manifestations were eligible.

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