Publications by authors named "Paul Nestadt"
Article Synopsis
- The study focuses on the high prevalence of obsessive-compulsive disorder (OCD) among pregnant and postpartum women and emphasizes the importance of efficient screening tools for early detection in perinatal care.
- Researchers evaluated the 4-item Obsessive Compulsive Inventory (OCI-4) for its reliability, validity, and diagnostic sensitivity through assessments at various stages of pregnancy and postpartum.
- Results indicate that the OCI-4 is a reliable and effective screening tool for identifying OCD symptoms in perinatal women, with a specific score of 3 providing optimal sensitivity and specificity for detection.
Article Synopsis
- Obsessive-compulsive disorder (OCD) affects about 1% of people and has a strong genetic component, but previous studies have not fully explained its genetic causes or biological mechanisms.
- A large genome-wide association study (GWAS) analyzed data from over 53,000 OCD cases and over 2 million control participants, identifying 30 significant genetic markers related to OCD and suggesting a 6.7% heritability from SNPs.
- The research also found 249 candidate risk genes linked to OCD, particularly in specific brain regions, and showed genetic correlations with various psychiatric disorders, laying the groundwork for further studies and potential treatments.
Objective: To describe the prevalence of diagnosed depression, anxiety, bipolar disorder, and schizophrenia in people with HIV (PWH) and the differences in HIV care continuum outcomes in those with and without mental health disorders (MHDs).
Design: Observational study of participants in the North American AIDS Cohort Collaboration on Research and Design.
Methods: PWH (≥18 years) contributed data on prevalent schizophrenia, anxiety, depressive, and bipolar disorders from 2008 to 2018 based on International Classification of Diseases code mapping.