Investigating the association of VHL gene variants with disease risk and clinicopathological outcomes in ccRCC patients from West Bengal, India.

Background: Clear cell renal cell carcinoma (ccRCC) is a prevalent and aggressive malignancy, with the von Hippel-Lindau (VHL) gene playing a critical role in its pathogenesis. However, the association between VHL gene variants and sporadic ccRCC risk remains unexplored in the Indian population. This study aimed to investigate the somatic and germline variants of the VHL gene in sporadic ccRCC patients from West Bengal, India, and their association with disease risk and clinicopathological parameters.

Novel Variants of IGF2 Gene Are Linked With Neural Tube Defects-An In Silico to Clinical Approach in West Bengal, India.

Background: Neural tube defects (NTDs) are defined as an incomplete closure of the neural tube (NT), with a prevalence of 1.2 per 1000 live births around the world. Methylation of the maternally imprinted gene Insulin-like growth factor 2 (IGF2) is one of the epigenetic mechanisms that contribute significantly to the development of NTDs.

An experimental comparison on the effectiveness of various levels of simulator fidelity on ab initio pilot training.

Despite recent advances in technology use for education and training, the approach to pilot training over the past several decades has largely remained unchanged. Student pilots complete their training in actual aircraft, with very few flight hours conducted in flight training devices. This study aimed to investigate the effectiveness of various levels of simulator fidelity on ab initio pilot training.

Moiré band structure engineering using a twisted boron nitride substrate.

Applying long wavelength periodic potentials on quantum materials has recently been demonstrated to be a promising pathway for engineering novel quantum phases of matter. Here, we utilize twisted bilayer boron nitride (BN) as a moiré substrate for band structure engineering. Small-angle-twisted bilayer BN is endowed with periodically arranged up and down polar domains, which imprints a periodic electrostatic potential on a target two-dimensional (2D) material placed on top.

Ligand Assisted Co(II)-Catalyzed Multicomponent Synthesis of Substituted Pyrroles and Pyridines.

Herein, we describe a sustainable Co(II)-catalyzed synthesis of pyrroles and pyridines. Using a Co(II)-catalyst [Co (L)Cl] (1 a) bearing redox-active 2-(phenyldiazenyl)-1,10-phenanthroline) (L) scaffold, various substituted pyrroles and pyridines were synthesized in good yields, taking alcohol as one of the primary feedstock. Pyrroles were synthesized by the equimolar reaction of 2-amino and secondary alcohols.

Microbial flora surrounding orthodontic temporary skeletal anchorage devices: A systematic review.

Aim: The oral cavity harbours distinct microorganisms, which create a unique microenvironment. These microorganisms might trigger inflammatory reactions in the host, potentially leading to inflammation that can question the stability of temporary skeletal anchorage devices(TSADs). This study aimed to systematically review the literature on the type of microorganisms around TSADs.

Zn(II)-Stabilized Azo-Anion Radical-Catalyzed Dehydrogenative Synthesis of Olefins.

Herein, we describe a Zn-catalyzed atom-economical, inexpensive, and sustainable method for preparing a broad spectrum of substituted olefins utilizing alcohols as the main precursor. Using a Zn(II) complex [ZnLCl] () of the redox-noninnocent ligand 2-((4-chlorophenyl)diazenyl)-1,10-phenanthroline (), various ()-olefins were prepared in good yields by coupling alcohols with sulfones and aryl cyanides under an inert atmosphere. Under an aerial atmosphere, vinyl nitriles were isolated in up to 82% yield reacting alcohols with benzyl cyanides in the presence of .

[Post-Intensive Care Syndrome: functional impairments of critical illness survivors].

With a decrease in mortality of critically ill patients in recent years, intensive care medicine research has shifted its focus on functional impairments of intensive care units (ICU) survivors. ICU survivorship is characterized by long-term impairments of cognition, mental health, and physical health. Since 2012, these impairments have been summarized with the umbrella term Post-Intensive Care Syndrome (PICS).

Bilateral Traumatic Posterior Hip Dislocation - A Case Report.

Introduction: Although posterior dislocation of the hip is common, bilateral posterior hip dislocation in children is an infrequent presentation. Early diagnosis and treatment are of paramount importance to prevent complications. Here, we report a case of traumatic bilateral posterior hip dislocation following a high-velocity motor vehicle accident.

Rendering Proteins Fluorescent Inconspicuously: Genetically Encoded 4-Cyanotryptophan Conserves Their Structure and Enables the Detection of Ligand Binding Sites.

Cyanotryptophans (CN-Trp) are privileged multimodal reporters on protein structure. They are similar in size to the canonical amino acid tryptophan and some of them exhibit bright fluorescence which responds sensitively to changes in the environment. We selected aminoacyl-tRNA synthetases specific for 4-, 5-, 6-, and 7-CN-Trp for high-yield in vivo production of proteins with a single, site-specifically introduced nitrile label.

Role of hypercoagulability in multifocal osteonecrosis.

Bone infarction describes bone marrow necrosis that occurs within a long bone's metaphysis or diaphysis. Multiple causative factors lead to ischaemia and subsequent necrosis of bone marrow. The role of hypercoagulability in bone ischaemia is a well-established phenomenon.

A qualitative exploration of barriers and facilitators to inclusion of dentistry in a regional shared health care record.

Objectives: To explore stakeholders' perceived barriers and facilitators to the inclusion of dental services in the Great North Care Record (GNCR) by identifying the stakeholders, exploring their perspectives and using the findings to inform integration of dental services in GNCR.

Methods: Qualitative online interview study with inductive thematic analysis.

Results: Twelve stakeholders identified through purposive sampling participated.

Non-Abelian Fractionalization in Topological Minibands.

Motivated by the recent discovery of fractional quantum anomalous Hall states in moiré systems, we consider the possibility of realizing non-Abelian phases in topological minibands. We study a family of moiré systems, skyrmion Chern band models, which can be realized in two-dimensional semiconductor-magnet heterostructures and also capture the essence of twisted transition metal dichalcogenide homobilayers. We show using many-body exact diagonalization that, in spite of strong Berry curvature variations in momentum space, the non-Abelian Moore-Read state can be realized at half filling of the second miniband.

Lectin Functionalised Iron Magnetic Nanoparticle-Based Sperm Selection: A Potential Technique to Improve Bull Sperm Quality In Vitro.

Premature acrosomal exocytosis in cryopreserved semen is one of the reasons attributed to low fertility among livestock. In the present study, we attempted to enhance the cryopreserved semen quality by selective removal of acrosome-reacted spermatozoa using FITC-PNA conjugated iron magnetic nanoparticles (MNPs). Further, the effect of nano purification on other sperm functional attributes was also assessed.

Copper mitigates salinity stress by regulating water status, photosynthetic pigments and ion homeostasis and increases the yield of Eggplant (Solanum melongena).

Eggplant (Solanum melongena) is moderately sensitive to salinity. Seed priming and exogenous supplementation are technique that enhances germination, growth, and crop yield by overcoming salt stress. Therefore, this study was designed to understand the role of seed priming and copper (Cu) supplementation in modulating salt tolerance in eggplant.

Cellular and extracellular proteomic profiling of paradoxical low-flow low-gradient aortic stenosis myocardium.

Aims: Patients with severe aortic stenosis (AS), low transvalvular flow (LF) and low gradient (LG) with normal ejection fraction (EF)-are referred to as paradoxical LF-LG AS (PLF-LG). PLF-LG patients develop more advanced heart failure symptoms and have a worse prognosis than patients with normal EF and high-gradient AS (NEF-HG). Despite its clinical relevance, the mechanisms underlying PLF-LG are still poorly understood.

Scar/WAVE drives actin protrusions independently of its VCA domain using proline-rich domains.

Cell migration requires the constant modification of cellular shape by reorganization of the actin cytoskeleton. Fine-tuning of this process is critical to ensure new actin filaments are formed only at specific times and in defined regions of the cell. The Scar/WAVE complex is the main catalyst of pseudopod and lamellipodium formation during cell migration.

Molecular responses of seaweeds to biotic interactions: A systematic review.

Seaweed farming is the single largest aquaculture commodity with >30 million tonnes produced each year. Furthermore, the restoration of lost seaweed forests is gaining significant momentum, particularly for kelps in warming temperate areas. Whether in aquaculture settings, following restoration practices, or in the wild, all seaweeds undergo biotic interactions with a diverse range of co-occurring or cocultured organisms.