Publications by authors named "Paul Mh Tran"
Multiple cross-sectional and longitudinal studies have shown that serum levels of the chemokine ligand 2 (CCL-2) are associated with type 1 diabetes (T1D), although the direction of effect differs. We assessed CCL-2 serum levels in a longitudinal cohort to clarify this association, combined with genetic data to elucidate the regulatory role of CCL-2 in T1D pathogenesis. The Diabetes Autoimmunity Study in the Young (DAISY) followed 310 subjects with high risk of developing T1D.
View Article and Find Full Text PDFArticle Synopsis
- Survival rates for newly diagnosed cervical cancer, particularly squamous cell carcinoma (SCCC), have not improved significantly in recent decades, prompting researchers to find prognostic genes that could help predict patient outcomes.
- An analysis of RNA-sequencing data from 203 patients led to the identification of 42 high-risk genes, with a focus on those whose expression levels could indicate considerable survival differences; a machine learning approach produced a transcriptomic risk score (TRS) based on 9 of these genes for better survivability predictions.
- Findings revealed that TRS was a more reliable predictor of mortality than traditional clinical factors, with specific high-risk groups identified, including 18% of earlier-stage patients classified as high-risk based on their TR