Moderators and mediators of the association between the obesogenicity of neighbourhoods and weight status in Dutch adults.

This study aimed to assess sociodemographic, personality, and psychological moderators, and lifestyle behavioural mediators, of the association between obesogenicity of neighbourhoods and weight status in Dutch adults. This cross-sectional study used baseline data of 150,506 adult participants of the Lifelines study. To quantify obesogenicity of Dutch neighbourhoods, the Obesogenic Built Environment CharacterisTics (OBCT) index was used, calculated for 1000 m circular buffers around participant's residencies.

Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults.

The generation and maintenance of protective immunity is a dynamic interplay between host and environment that is impacted by age. Understanding fundamental changes in the healthy immune system that occur over a lifespan is critical in developing interventions for age-related susceptibility to infections and diseases. Here, we use multi-omic profiling (scRNA-seq, proteomics, flow cytometry) to examined human peripheral immunity in over 300 healthy adults, with 96 young and older adults followed over two years with yearly vaccination.

Associations between the neighbourhood food environment and cardiovascular disease: a systematic review.

Aims: To systematically review the current evidence on the association between the neighbourhood food environment and cardiovascular disease (CVD) in adults.

Methods And Results: We searched the literature databases CINAHL, MEDLINE, and EMBASE for studies published between 1 January 2000 and 1 May 2022. Studies focusing on the indoor home, workplace, or school food environment were excluded.

The built environment and cardiovascular disease: an umbrella review and meta-meta-analysis.

Aims: To provide a comprehensive overview of the current evidence on objectively measured neighbourhood built environment exposures in relation to cardiovascular disease (CVD) events in adults.

Methods And Results: We searched seven databases for systematic reviews on associations between objectively measured long-term built environmental exposures, covering at least one domain (i.e.

A comprehensive platform for analyzing longitudinal multi-omics data.

Longitudinal bulk and single-cell omics data is increasingly generated for biological and clinical research but is challenging to analyze due to its many intrinsic types of variations. We present PALMO ( https://github.com/aifimmunology/PALMO ), a platform that contains five analytical modules to examine longitudinal bulk and single-cell multi-omics data from multiple perspectives, including decomposition of sources of variations within the data, collection of stable or variable features across timepoints and participants, identification of up- or down-regulated markers across timepoints of individual participants, and investigation on samples of same participants for possible outlier events.

Longitudinal immune dynamics of mild COVID-19 define signatures of recovery and persistence.

SARS-CoV-2 has infected over 200 million and caused more than 4 million deaths to date. Most individuals (>80%) have mild symptoms and recover in the outpatient setting, but detailed studies of immune responses have focused primarily on moderate to severe COVID-19. We deeply profiled the longitudinal immune response in individuals with mild COVID-19 beginning with early time points post-infection (1-15 days) and proceeding through convalescence to >100 days after symptom onset.

Mediterranean isolation preconditioning the Earth System for late Miocene climate cooling.

A global Neogene cooling trend culminated ~7 million years ago with the onset of Greenland glaciation. Increased ocean-atmosphere interaction and low- to high-latitude circulation are thought to be key factors in reorganizing late Miocene global temperature and precipitation patterns, but the drivers of this reorganization have yet to be identified. Here, we present new information about the evolution of the Atlantic-Mediterranean gateway that generated Mediterranean overflow.

Diagnostic efficiency of the Sysmex XN WPC channel for the reduction of blood smears.

Background: Several small studies showed that the WPC (white precursor cell) channel in the Sysmex haematology analyser for leukocyte differentiation analysis leads to a significant reduction of microscopic blood smears. We determined the added value of the WPC channel for blood smear reduction in a large teaching hospital and whether this reduction was cost-effective and save.

Methods: Retrospectively, for 7850 leukocyte differentiation orders the percentage of samples resulting in a WPC analysis and the outcomes of the WPC analysis were analysed and compared with the blood smear results.

Resolution of a complex mediastinal pseudocyst in a patient with alcohol-related chronic pancreatitis following abstinence from alcohol.

We describe a 55-year-old patient with alcoholic chronic pancreatitis, a large mediastinal pseudocyst and a hemorrhagic pleural effusion. A single thoracocentesis and withdrawal of alcohol without other conservative or invasive measures resulted in a complete resolution of the pleural effusion and the mediastinal pseudocyst, which to our knowledge has not been described before.

Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study.

We conducted a sib pair study in very old subjects for the purpose of mapping longevity loci. In the present analysis, we explore whether our recruitment strategy has resulted in a population enriched for a heritable component for exceptional longevity. Our study includes families with at least two long-living siblings (men aged 89 years or above; women aged 91 years or above).

Building syntactic structures in speaking: a bilingual exploration.

In a series of three experiments we investigated syntactic priming using a sentence recall task. Participants read and memorized a target sentence for later recall. After reading a prime sentence and engaging in a distraction task, they were asked to produce the target sentence aloud.

Energy Levels, Wave Functions, Dipole and Quadrupole Transitions of Trivalent Gadolinium Ions in Sapphire.

A computation is made of energy levels, wave functions and transition matrix elements of the Gd ion in AlO. The crystal field parameters are taken from Geschwind and Remeika's paramagnetic resonance experiments. The transition probabilities are given for dipole radiation in three polarization directions.

Energy Levels, Wave Functions, Dipole and Quadrupole Transitions of Fe Ions in Sapphire.

A computation is made of energy levels, wave functions and transition probabilities of the Fe ion in AlO. The crystal field parameters used were those determined by Symmons and Bogle at 4 K. The magnetic field direction is described by the angles and indicating the directions with respect to and around the axis of the crystal.

Techniques for the Growth of Large Single Crystals of Potassium of High Purity.

The preparation of large, high purity, single crystals of potassium is described. First, high initial purity is obtained by careful zone refining. Then, a modification of the Bridgman technique is applied which leads to crystals with resistivity ratios up to 6800 at 4.

Calculation of the Higher Order Dipole-Dipole Effect in Paramagnetic Crystals.

This report is an attempt to investigate the influence of dipole-dipole coupling in a paramagnetic spin system at low temperatures. It consists of two parts. The first part is a discussion of the use of for a system with mutual interaction.