Publications by Paul Magogo Tambwe

Publications by authors named "Paul Magogo Tambwe"

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In silico evidence of bitopertin's broad interactions within the SLC6 transporter family.

Gustavo Almeida de Carvalho Paul Magogo Tambwe Lucas Rodrigues Couto Nascimento Bruna Kelly Pedrosa Campos Raphaela Almeida Chiareli

J Pharm Pharmacol

September 2024

The Glycine Transporter Type 1 (GlyT1) significantly impacts central nervous system functions, influencing glycinergic and glutamatergic neurotransmission. Bitopertin, the first GlyT1 inhibitor in clinical trials, was developed for schizophrenia treatment but showed limited efficacy. Despite this, bitopertin's repositioning could advance treating various pathologies.

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