Horizontal diffusion elutriation: a new size-separation technique for preparation of rodent-respirable fibers for animal testing.

Short-and long-term animal experiments are used to examine the toxicology and biopersistence of various types of fibers. In order to ensure an adequate exposure dose for testing, modern experimental protocols specify that the exposure aerosol (in an inhalation test) or the fibers (in an intratracheal instillation [IT] test) must contain at least a minimum concentration of long (> 20 mum) rodent-respirable fibers. As produced and handled, most fibers contain a distribution of diameters and lengths, only some of which are both long and rodent-respirable.

Categorization and nomenclature of vitreous silicate wools.

There is substantial interest among government agencies in categorizing fibers for hazard classification purposes, particularly the commercially important synthetic vitreous fibers (e.g., rock wool, slag wool, glass wool, and refractory ceramic fibers).